Effect of light transition metal complexes of methanesulfonic acid hydrazide on the viability of yeast Saccharomyces cerevisiae.

The effect of methanesulfonic acid hydrazide (MSH) and its complexes [M(MSH)4Cl2] (M = Mn, Fe, Co, Ni) and [Zn(MSH)2Cl2] on culture growth suppression and viability (Colony Forming Units) of Saccharomyces cerevisiae has been studied. The highest culture growth suppression was exhibited by [Co(MSH)4Cl2], whereas the most cytotoxic appeared [Mn(MSH)4Cl2]. The changes in cell morphology were also traced by means of FACS analysis.