Publications by authors named "Daniel Mutua"
Background: Chemotherapy used to treat malignancy can lead to loss of skeletal muscle mass and reduced force production, and can reduce bone volume in mice. We have shown that bone-muscle crosstalk is a key nexus in skeletal muscle function and bone homeostasis in osteolytic breast cancer bone metastases. Because chemotherapy has significant negative side effects on bone mass, and because bone loss can drive skeletal muscle weakness, we have examined the effects of chemotherapy on the musculoskeletal system in mice with breast cancer bone metastases.
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- Humoral immune responses are crucial for immunity against malaria, and understanding impairments in these responses can aid in vaccine development.
- The study compared immune responses to 483 malaria antigens between adults in two regions with differing malaria transmission levels, finding significant differences in reactivity in those with higher transmission.
- Using protein microarrays, researchers identified several reactive antigens and noted that reductions in CD4(+) T-cell counts did not greatly affect malaria-specific immunity, indicating potential vaccine targets.