Publications by authors named "Daniel Monyak"
Article Synopsis
- The age of newly diagnosed breast tumors provides important insights into their causes and potential outcomes, as it reflects the time from when the tumor starts growing until it is detected.
- Researchers estimate this age using a novel method based on epigenetic changes rather than traditional age-related markers, revealing that younger tumors tend to be more aggressive with higher growth rates and instability.
- These findings highlight the potential of this epigenetic approach for better risk assessment and early detection of breast cancer by distinguishing between aggressive young tumors and older, more stable ones.
Ductal carcinoma in situ (DCIS) and invasive breast cancer share many morphologic, proteomic, and genomic alterations. Yet in contrast to invasive cancer, many DCIS tumors do not progress and may remain indolent over decades. To better understand the heterogenous nature of this disease, we reconstructed the growth dynamics of 18 DCIS tumors based on the geo-spatial distribution of their somatic mutations.
View Article and Find Full Text PDFPremise: Robust standards to evaluate quality and completeness are lacking in eukaryotic structural genome annotation, as genome annotation software is developed using model organisms and typically lacks benchmarking to comprehensively evaluate the quality and accuracy of the final predictions. The annotation of plant genomes is particularly challenging due to their large sizes, abundant transposable elements, and variable ploidies. This study investigates the impact of genome quality, complexity, sequence read input, and method on protein-coding gene predictions.
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