Multidisciplinary Teams in Musculoskeletal Infection - From a Pathologist's Perspective.

Multidisciplinary team (MDT) meetings have emerged as a promising approach for the treatment of cancer patients. These meetings involve a team of healthcare professionals from different disciplines working together to develop a holistic, patient-centered treatment. Although MDT meetings are well established in oncology, they play a minor role in other diseases.

Comparative Analysis of Mitochondria Surrounding the Intercalated Discs in Heart Diseases-An Ultrastructural Pilot Study.

Background: Mitochondria play a crucial role in adapting to fluctuating energy demands, particularly in various heart diseases. This study investigates mitochondrial morphology near intercalated discs in left ventricular (LV) heart tissues, comparing samples from patients with sinus rhythm (SR), atrial fibrillation (AF), dilated cardiomyopathy (DCM), and ischemic cardiomyopathy (ICM).

Methods: Transmission electron microscopy was used to analyze mitochondria within 0-3.

Prediction of heart transplant rejection from routine pathology slides with self-supervised deep learning.

Aims: One of the most important complications of heart transplantation is organ rejection, which is diagnosed on endomyocardial biopsies by pathologists. Computer-based systems could assist in the diagnostic process and potentially improve reproducibility. Here, we evaluated the feasibility of using deep learning in predicting the degree of cellular rejection from pathology slides as defined by the International Society for Heart and Lung Transplantation (ISHLT) grading system.

Ultrastructural Evidence of Mitochondrial Dysfunction in Osteomyelitis Patients.

Osteomyelitis is a difficult-to-treat disease with high chronification rates. First studies suggest increases in mitochondrial fission and mitochondrial dysfunction as possible contributors to the accumulation of intracellular reactive oxygen species and thereby to the cell death of infected bone cells. The aim of the present study is to analyze the ultrastructural impact of bacterial infection on osteocytic and osteoblastic mitochondria.

Structural Analysis of Mitochondrial Dynamics-From Cardiomyocytes to Osteoblasts: A Critical Review.

Mitochondria play a crucial role in cell physiology and pathophysiology. In this context, mitochondrial dynamics and, subsequently, mitochondrial ultrastructure have increasingly become hot topics in modern research, with a focus on mitochondrial fission and fusion. Thus, the dynamics of mitochondria in several diseases have been intensively investigated, especially with a view to developing new promising treatment options.

Validation of oil fate and mass balance for the Deepwater Horizon oil spill: Evaluation of water column partitioning.

Model predictions of oil transport and fate for the 2010 Deepwater Horizon oil spill (Gulf of Mexico) were compared to field observations and absolute and relative concentrations of oil compounds in samples from 900 to 1400 m depth <11 km from the well. Chemical partitioning analyses using quantitative indices support a bimodal droplet size distribution model for oil released during subsea dispersant applications in June with 74% of the mass in >1 mm droplets that surfaced near the spill site within a few hours, and 1-8% as <0.13 mm microdroplets that remained below 900 m.

Self in medicine: Determinants of physician well-being and future directions in improving wellness.

Context: Medicine, a profession dedicated to the wellness of patients, is struggling with a crisis of physician and trainee wellness. Physicians and trainees are burning out at alarming rates. Historically, medicine has been characterised by challenging working conditions and inattention to physician wellness and self-care.

Intracellular in Osteoblasts in a Clinical Sample from a Patient with Chronic Osteomyelitis-A Case Report.

The pathophysiological role of intracellular bacteria in osteomyelitis is still a matter of debate. Here, we demonstrate for the first time the presence of internalized into osteoblasts in human tissue samples of a case with a chronic osteomyelitis using ultrastructural transmission electron microscope analysis.

Oil fate and mass balance for the Deepwater Horizon oil spill.

Based on oil fate modeling of the Deepwater Horizon spill through August 2010, during June and July 2010, ~89% of the oil surfaced, ~5% entered (by dissolving or as microdroplets) the deep plume (>900 m), and ~6% dissolved and biodegraded between 900 m and 40 m. Subsea dispersant application reduced surfacing oil by ~7% and evaporation of volatiles by ~26%. By July 2011, of the total oil, ~41% evaporated, ~15% was ashore and in nearshore (<10 m) sediments, ~3% was removed by responders, ~38.

Impact of work hours and sleep on well-being and burnout for physicians-in-training: the Resident Activity Tracker Evaluation Study.

Objective: The Resident Activity Tracker Evaluation (RATE) is a prospective observational study evaluating the impact of work hours, sleep and physical activity on resident well-being, burnout and job satisfaction.

Background: Physician burnout is common and its incidence is increasing. The impact of work hours and sleep on resident well-being and burnout remains elusive.

Application of an Integrated Blowout Model System, OILMAP DEEP, to the Deepwater Horizon (DWH) Spill.

OILMAP DEEP, an integrated system of models (pipeline release, blowout plume, dispersant treatment, oil droplet size distribution, and fountain and intrusion), was applied to the Deepwater Horizon (DWH) oil spill to predict the near field transport and fate of the oil and gas released into the northeastern Gulf of Mexico. The model included multiple, time dependent releases from both the kink and riser, with the observed subsurface dispersant treatment, that characterized the DWH spill and response. The blowout model predictions are in good agreement with the available observations for plume trapping height and the major characteristics of the intrusion layer.

Ipsilateral Motor Innervation Discovered Incidentally on Intraoperative Monitoring: A Case Report.

Background And Importance: Lesions in the corticospinal tract above the decussation at the medullary pyramids almost universally produce contralateral deficits. Rare cases of supratentorial lesions causing ipsilateral motor deficits have been reported previously, but only ever found secondary to stroke or congenital pyramidal tract malformations.

Clinical Presentation: Herein, we report a case of ipsilateral corticospinal tract innervation discovered incidentally with intraoperative monitoring during a microsurgical resection of a vestibular schwannoma.

Clinical and Radiographic Factors Predicting Hearing Preservation Rates in Large Vestibular Schwannomas.

Objectives Postoperative hearing preservation rates for patients with large vestibular schwannomas range from 0 to 43%. The clinical and radiographic factors predicting hearing preservation in smaller vestibular schwannomas are well described; however, their importance in larger tumors is unclear. We investigated factors predicting hearing preservation in large vestibular schwannomas.

Patient and surgeon radiation exposure during spinal instrumentation using intraoperative computed tomography-based navigation.

Background Context: Imaging modalities used to visualize spinal anatomy intraoperatively include X-ray studies, fluoroscopy, and computed tomography (CT). All of these emit ionizing radiation.

Purpose: Radiation emitted to the patient and the surgical team when performing surgeries using intraoperative CT-based spine navigation was compared.

Economic evaluation comparing intraoperative cone beam CT-based navigation and conventional fluoroscopy for the placement of spinal pedicle screws: a patient-level data cost-effectiveness analysis.

Background Context: Pedicle screws are routinely used in contemporary spinal surgery. Screw misplacement may be asymptomatic but is also correlated with potential adverse events. Computer-assisted surgery (CAS) has been associated with improved screw placement accuracy rates.

Bilateral Pedicle and Crossed Translaminar Screws in C2.

Multiple techniques exist for the fixation of C2, including axial pedicle screws and bilateral translaminar screws. We describe a novel method of incorporating both the translaminar and pedicle screws within C2 to improve fixation to the subaxial spine in patients requiring posterior cervical instrumentation for deformity correction or instability. We report three cases of patients with cervical spinal instability, who underwent cervical spine instrumentation for stabilization and/or deformity correction.

The contemporary practice of psychiatric surgery: results from a global survey of functional neurosurgeons.

Background: Interest in neurosurgery for psychiatric diseases (NPD) has grown globally. We previously reported the results of a survey of North American functional neurosurgeons that evaluated general attitudes towards NPD and the future directions of the field.

Objectives: The purpose of this study was to expand on our previous work and obtain a snapshot in time of global attitudes towards NPD among practicing functional neurosurgeons.

Percutaneous trigeminal rhizotomy for facial pain secondary to head and neck malignancy.

Background: Nearly 80% of patients with head and neck cancers experience facial pain related to their tumor or treatment. The majority obtain pain relief with appropriate medical treatment. Occasionally some remain refractory to all analgesics or cannot tolerate the accompanying side effects.

Revision rates after endoscopic sinus surgery: a recurrence analysis.

Objectives: Chronic rhinosinusitis with nasal polyposis is often refractory to medical and surgical management, especially in patients with asthma and aspirin intolerance. We used a contemporary database to investigate recurrence and revision surgery rates following endoscopic sinus surgery.

Methods: We performed a cohort study using a survival analysis technique.

The contemporary practice of psychiatric surgery: results from a survey of North American functional neurosurgeons.

Background: Deep brain stimulation (DBS) for psychiatric indications is becoming increasingly safe and effective. As a result, the treatment of these conditions by neurosurgeons is becoming more widespread and a larger part of the functional neurosurgeons' practice. Given the troubled history of the field and its current renaissance, it is important to evaluate current practices, to serve as a baseline for future comparison, and to gauge changing cultural attitudes towards invasive neuromodulation.