Proton density fat fraction (PDFF) MRI for differentiation of benign and malignant vertebral lesions.

Objectives: To investigate whether proton density fat fraction (PDFF) measurements using a six-echo modified Dixon sequence can help to differentiate between benign and malignant vertebral bone marrow lesions.

Methods: Sixty-six patients were prospectively enrolled in our study. In addition to conventional MRI at 3.