Publications by authors named "Daniel Ll Hughes"

. Ciliated hepatic foregut cysts (CHFCs) are uncommon cystic lesions within the liver. CHFCs can undergo a malignant transformation to form a primary squamous cell carcinoma of the liver.

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Purpose: Refractory abdominal pain is a cardinal symptom of chronic pancreatitis (CP). Management strategies revolve around pain mitigation and resolution. Emerging evidence from observational studies highlights that surgery may result in superior pain relief when compared to endoscopic therapy; however, its impact on long-term quality of life or functional outcome has yet to be determined.

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Article Synopsis
  • A meta-analysis was conducted to evaluate the effectiveness of adjuvant therapy on overall survival (OS) in patients with resected Invasive Intraductal Papillary Mucinous Neoplasms (i-IPMN), highlighting conflicting evidence on its role.* -
  • The analysis included ten studies and found no significant improvement in OS for the overall patient group (HR = 1; P = 0.98), though some subgroups, particularly those with aggressive disease features like nodal involvement, showed potential benefits.* -
  • The findings suggest that while adjuvant therapy may not improve survival for all i-IPMN patients, it may be beneficial for those with more severe disease characteristics, indicating a need for tailored treatment approaches
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Conventional static culture fails to replicate the physiological conditions that exist in vivo. Recent advances in biomedical engineering have resulted in the creation of novel dynamic culturing systems that permit the recapitulation of normal physiological processes ex vivo. Whilst the physiological benefit for its use in the culture of two-dimensional cellular monolayer has been validated, its role in the context of primary human tissue culture has yet to be determined.

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Purpose: Developments in surgical techniques and neoadjuvant treatment have enabled an increasing proportion of patients with rectal cancer to undergo sphincter-sparing resections. The avoidance of a permanent stoma can come at the cost of poor bowel function which can significantly impact patients' quality of life. The objective of this study was to identify the incidence and risk factors for the development of bowel dysfunction following rectal cancer surgery.

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