Publications by authors named "Daniel Lewis"
Background: Prior case series suggest that a 5-day course of oral Paxlovid (nirmatrelvir/ritonavir) benefits some people with Long COVID, within and/or outside of the context of an acute reinfection. To the best of our knowledge, there have been no prior case series of people with Long COVID who have attempted longer courses of nirmatrelvir/ritonavir.
Methods: We documented a case series of 13 individuals with Long COVID who initiated extended courses (>5 days; range: 7.
Skeletal fractures are traumatic injuries that are widely accepted as requiring acute treatment to avoid long-term disability and dysfunction. There are a number of soft-tissue injuries or non-traditional fractures, frequently treated by sports medicine surgeons, which additionally require treatment in an expedited fashion in order to optimize healing and function. Sports medicine injuries of the lower extremity requiring acute treatment include, but are not limited to, irreducible shoulder dislocations, acute traumatic rotator cuff tears, posterior sternoclavicular joint dislocations, high grade acromioclavicular joint dislocations, pectoralis major tendon ruptures, distal biceps tendon ruptures, and triceps tendon ruptures.
View Article and Find Full Text PDFSkeletal fractures are traumatic injuries that are widely accepted as requiring acute treatment to avoid long-term disability and dysfunction. There are a number of soft-tissue injuries or non-traditional fractures, frequently treated by sports medicine surgeons, which additionally require treatment in an expedited fashion in order to optimize healing and function. Sports medicine injuries of the lower extremity requiring acute treatment include, but are not limited to, multiligamentous knee injuries, proximal hamstring ruptures, quadriceps tendon ruptures, patellar sleeve avulsions, patellar tendon ruptures, tibial spine avulsions, posterior cruciate ligament avulsions, bucket handle meniscus tears, and achilles tendon ruptures.
View Article and Find Full Text PDFThe authors hypothesized that the infection rates of open hand fractures treated in a delayed manner would not be higher than those treated immediately. The authors performed a retrospective chart review of patients treated between January 2008 and July 2014 at a Level 1 Trauma Center. Delayed (> 24 hours) versus early (< 24 hours) surgical treatment groups were identified for comparison to determined infection rates.
View Article and Find Full Text PDFPurpose: To evaluate the current utilization trends of practicing surgeons performing and lateral extra-articular augmentation (LEA) at the time of primary anterior cruciate ligament reconstruction (ACLR).
Methods: The survey was distributed via e-mail in August 2023 to members of the Arthroscopy Association of North America who identified as knee surgeons and was available online on the Arthroscopy Association of North America website from January to September 2023. The 18-question survey was designed regarding surgeons' surgical utilization patterns of LEA during ACLR.
Article Synopsis
- The study aimed to evaluate the effectiveness and precision of using 3D-printed guides versus freehand methods for placing Kirschner wires in the femurs of dogs, focusing on novice versus experienced surgeons.!
- It involved creating 3D models of dog femurs, followed by virtual surgical planning, and then comparing the results of wire placements with freehand techniques and those guided by 3D-printed models.!
- Results indicated that 3D-printed guides led to quicker procedures, fewer complications, and better accuracy in wire placement, highlighting the need for further research in practical applications for surgeries in dogs.!
Purpose: To investigate the incidence of heterotopic ossification (HO) in patients prescribed prophylactic nonsteroidal anti-inflammatory drugs (NSAIDs), both before and after the introduction of a standardized education protocol.
Methods: A retrospective review was conducted using a database of hip arthroscopy patients treated by a single surgeon at an academic hospital from 2015 to 2023. The inclusion criteria were (1) primary hip arthroscopy for the treatment of femoroacetabular impingement, (2) completion of a 2-week course of prophylactic postoperative NSAIDs (500 mg of naproxen twice daily), and (3) availability of follow-up radiographs at the 6-month postoperative visit.
Article Synopsis
- Researchers developed an analog of a small molecule called UM101, named GEn-1124, which has better solubility and binding affinity to the p38a MAPK protein, known for its role in inflammation.
- GEn-1124 shows significant improvements over UM101, such as an 18-fold increase in binding affinity, enhanced stability, and better lung protection, resulting in improved survival rates in mouse models of acute lung injury.
- The study reveals that GEn-1124 operates through a novel mechanism by destabilizing the p38a:MK2 complex, altering gene expression, and promoting enhanced signaling within the cell's nucleus.
Objective: The aim of the present study was to report the outcomes and complications of minimally invasive tarsal arthrodesis (MITA) in dogs.
Study Design: Bi-institutional retrospective study.
Sample Population: A total of 15 client-owned dogs.
A non-reducible tibial tuberosity fracture is a rare complication of tibial tuberosity transposition performed during correcting of medial patella luxation (MPL) in dogs. This condition severely disrupts the quadriceps extensor mechanism, leading to significant pelvic limb lameness. An 11-year-old, 1.
View Article and Find Full Text PDFEngineered Skin Substitutes in Dermatologic Surgery: A Systematic Review.
Dermatol Surg
December 2024
Background: Artificial skin substitutes are a flexible alternative to autografting in Mohs micrographic surgery (MMS), but the characteristics and clinical outcomes of skin substitutes are not well defined.
Objective: Summarize clinical data of skin substitutes in MMS for cutaneous malignancy.
Methods: A MEDLINE/Embase/Web of Science search was conducted.
Objectives: Trauma screening is recommended for pregnant persons with opioid use disorder (OUD), but there is limited literature on screening results from buprenorphine treatment. This study's objectives were to 1) describe the types, and severity, of traumatic events reported and 2) evaluate the associations between trauma and health-related quality of life (HRQoL).
Methods: Baseline data from an ongoing trial were analyzed.
Objective: To compare the efficacy and clinical outcomes of computed tomography (CT)-based virtual surgical planning (VSP) and a three-dimensional (3D)-printed, patient-specific reduction system to conventional indirect reduction techniques for diaphyseal tibial fractures stabilized using minimally invasive plate osteosynthesis (MIPO) in dogs.
Study Design: A prospective clinical study with a historic control cohort.
Sample Population: Dogs undergoing MIPO stabilization of diaphyseal tibial fractures using a custom 3D-printed reduction system (3D-MIPO; n = 15) or conventional indirect reduction techniques (c-MIPO; n = 14).
Article Synopsis
- The study investigates the timing (T) of surgical evacuation in patients with traumatic intracranial hematoma (TICH) and its impact on mortality and neurological recovery, highlighting the lack of significant improvements in outcomes despite advancements in trauma care.
- A systematic review was conducted, analyzing 17 studies out of 1,838 screened, with mixed results regarding the association between shorter T and patient outcomes, indicating that shorter surgery times may not always lead to better results.
- The findings suggest that the 4-hour time cut-off for surgery might correlate with improved survival rates, but overall, there is limited contemporary evidence and no reduction in evacuation times over the last 33 years, necessitating further research on this key performance
Background: Nonauditory symptoms can be a prominent feature in patients with sporadic vestibular schwannoma (VS), but the cause of these symptoms is unknown. Inflammation is hypothesized to play a key role in the growth and symptomatic presentation of sporadic VS, and in this study, we investigated through translocator protein (TSPO) positron emission tomography (PET) whether inflammation occurred within the "normal appearing" brain of such patients and its association with tumor growth.
Methods: Dynamic PET datasets from 15 patients with sporadic VS (8 static and 7 growing) who had been previously imaged using the TSPO tracer [C]()-PK11195 were included.
Article Synopsis
- The study aimed to assess hip capsule thickness using advanced imaging in patients with and without hip dysplasia to see if there are differences between those with borderline and true dysplasia.
- Researchers analyzed data from 80 patients and found that those with dysplasia had significantly thinner hip capsules compared to those without, measuring 2.75 mm vs. 3.52 mm.
- The subanalysis indicated that there were no notable differences in capsular thickness between patients classified as having borderline dysplasia and those with true dysplasia, suggesting further research is needed to explore the implications of these findings on hip stability.