Effect of Unstable Loads on Stabilizing Muscles and Bar Motion During the Bench Press.

Lawrence, MA, Ostrowski, SJ, Leib, DJ, and Carlson, LA. Effect of unstable loads on stabilizing muscles and bar motion during the bench press. J Strength Cond Res 35(2S): S120-S126, 2021-Unstable loads are anecdotally used to increase muscle stabilizer strength and utilization; however, there is little evidence to support these claims.

A new model of multi-visceral and bone metastatic prostate cancer with perivascular niche targeting by a novel endothelial specific adenoviral vector.

While modern therapies for metastatic prostate cancer (PCa) have improved survival they are associated with an increasingly prevalent entity, aggressive variant PCa (AVPCa), lacking androgen receptor (AR) expression, enriched for cancer stem cells (CSCs), and evidencing epithelial-mesenchymal plasticity with a varying extent of neuroendocrine transdifferentiation. Parallel work revealed that endothelial cells (ECs) create a perivascular CSC niche mediated by juxtacrine and membrane tethered signaling. There is increasing interest in pharmacological metastatic niche targeting, however, targeted access has been impossible.

Mechanical comparison of iliosacral reconstruction techniques after sarcoma resection.

Background: Reconstruction of iliosacral defects following oncologic resection is a difficult clinical problem associated with a high incidence of failure. Technical approaches to this problem are heterogeneous and evidence supporting specific techniques is sparse. Maximizing construct stability may improve union rates and functional outcomes.

Nonlinear Analysis of an Unstable Bench Press Bar Path and Muscle Activation.

Lawrence, MA, Leib, DJ, Ostrowski, SJ, and Carlson, LA. Nonlinear analysis of an unstable bench press bar path and muscle activation. J Strength Cond Res 31(5): 1206-1211, 2017-Unstable resistance exercises are typically performed to improve the ability of stabilizing muscles to maintain joint integrity under a load.

A novel technique for the contrast-enhanced microCT imaging of murine intervertebral discs.

Disc degeneration is one of the leading factors that contribute to low back pain. Thus, the further understanding of the mechanisms contributing to degeneration of the intervertebral disc degeneration is critical for the development of therapies and strategies for treating low back pain. Rodent models are attractive for conducting mechanistic studies particularly because of the availability of genetically modified animals.

Thrombospondin-1 regulates bone homeostasis through effects on bone matrix integrity and nitric oxide signaling in osteoclasts.

Thrombospondin-1 (TSP1), an endogenous antiangiogenic, is a widely expressed secreted ligand with roles in migration, adhesion, and proliferation and is a target for new therapeutics. While TSP1 is present in the bone matrix and several TSP1 receptors play roles in bone biology, the role of TSP1 in bone remodeling has not been fully elucidated. Bone turnover is characterized by coordinated activity of bone-forming osteoblasts (OB) and bone-resorbing osteoclasts (OC).

The effects of load carriage and muscle fatigue on lower-extremity joint mechanics.

Unlabelled: Military personnel are commonly afflicted by lower-extremity overuse injuries. Load carriage and muscular fatigue are major stressors during military basic training.

Purpose: To examine effects of load carriage and muscular fatigue on lower-extremity joint mechanics during walking.

Effects of fatigue on golf performance.

The purpose of this study was to determine if body position, weight transfer, and/or pelvis/trunk rotations changed as a result of a golf specific fatiguing protocol and whether these changes affected resultant club head velocity at impact and shot consistency. Six male golfers and one female golfer participated in the study, who had a mean age, height, and body mass of 23.9 +/- 3.

Influence of fatigue and load carriage on mechanical loading during walking.

Load carriage and muscular fatigue are two major stressors experienced by military recruits during basic training. The purpose of this study was to assess the influences of load carriage and muscular fatigue on ground reaction forces and ground reaction loading rates during walking. Eighteen healthy males performed the following tasks in order: unloaded and unfatigued walking, loaded and unfatigued walking, fatiguing exercise, loaded and fatigued walking, and unloaded and fatigued walking.