Publications by authors named "Daniel L Weiner"
Busulfan is an alkylating agent used as part of conditioning chemotherapy regimens prior to allogeneic hematopoietic cell transplant (allo-HCT). Pharmacokinetic (PK)-guided test-dose strategies have been shown to improve the number of patients achieving busulfan exposure goals and improve clinical outcomes. However, current practices require extensive PK sampling.
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- Tacrolimus is an immunosuppressant used to prevent acute graft versus host disease in adults undergoing allogeneic hematopoietic stem cell transplantation (HCT), but no pharmacokinetic models specifically for HCT patients had been established before this study.
- The study aimed to adapt a existing population pharmacokinetic model from kidney transplantation to HCT, evaluate tacrolimus trough concentrations, and identify factors influencing its pharmacokinetics in HCT.
- By analyzing data from 252 patients, the study found that using observed trough concentrations improved patient outcomes and identified significant covariates like HLA matching and conditioning regimens that could inform future dose adjustments for HCT patients.
Cocaine (COC) is a psychostimulant with a high potential for abuse and addiction. Risk for COC use disorder is driven, in part, by genetic factors. Animal models of addiction-relevant behaviors have proven useful for studying both genetic and nongenetic contributions to drug response.
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