Asexual populations of the human malaria parasite, Plasmodium falciparum, use a two-step genomic strategy to acquire accurate, beneficial DNA amplifications.

Malaria drug resistance contributes to up to a million annual deaths. Judicious deployment of new antimalarials and vaccines could benefit from an understanding of early molecular events that promote the evolution of parasites. Continuous in vitro challenge of Plasmodium falciparum parasites with a novel dihydroorotate dehydrogenase (DHODH) inhibitor reproducibly selected for resistant parasites.

Photoinduced Reactions of Tri-tert-butylindium with (Diethylamino)trimethylstannane and (Di-n-butylamino)trimethylstannane.

The preparations of [(t-Bu)(2)InNEt(2)](2) and [(t-Bu)(2)InN(n-Bu)(2)](2) by the photoinduced reactions of (t-Bu)(3)In with Et(2)NSnMe(3) and (n-Bu)(2)NSnMe(3), respectively, have been investigated. The isolation and characterization of products other than [(t-Bu)(2)InNR(2)](2) in these reactions clearly indicate that the reactions of (t-Bu)(3)In with R(2)NSnMe(3) do not proceed by simple alkyltrimethyltin elimination. A possible radical mechanism for the formation of the byproducts has been suggested.