Publications by authors named "Daniel Kotas"
Article Synopsis
- * Severe TBI and penetrating head injuries are major risk factors for PTE, which can lead to poor health outcomes and increased social challenges.
- * In a study of 1,886 TBI patients, 178 (about 9.44%) were found to have PTE, but only a small percentage (10.7%) followed up with a neurologist after 6 months, indicating a need for improved patient follow-up care.
Unlabelled: The transcription factor, SOX10, plays an important role in the differentiation of neural crest precursors to the melanocytic lineage. Malignant transformation of melanocytes leads to the development of melanoma, and SOX10 promotes melanoma cell proliferation and tumor formation. SOX10 expression in melanomas is heterogeneous, and loss of SOX10 causes a phenotypic switch toward an invasive, mesenchymal-like cell state and therapy resistance; hence, strategies to target SOX10-deficient cells are an active area of investigation.
View Article and Find Full Text PDFUnlabelled: Lack of response and acquired resistance continue to be limitations of targeted and immune-based therapies. Pyroptosis is an inflammatory form of cell death characterized by the release of inflammatory damage-associated molecular patterns (DAMP) and cytokines via gasdermin (GSDM) protein pores in the plasma membrane. Induction of pyroptosis has implications for treatment strategies in both therapy-responsive, as well as resistance forms of melanoma.
View Article and Find Full Text PDFArticle Synopsis
- Developmental factors influence immune modulatory proteins in cancer, particularly in melanoma, revealing connections between embryonic development and immune evasion by cancer cells.
- The study focuses on SRY-box transcription factor 10 (SOX10), which is essential for melanoma growth and positively regulates immune-related targets like HVEM and CEACAM1.
- Knockout of Sox10 reduces tumor growth, particularly in immune-competent models, and its effects are partially linked to CD8+ T cells, with SOX10 levels inversely correlating with immune pathway activity in human melanoma samples.