Publications by authors named "Daniel J Sacks"
J Bone Miner Res
February 2009
Article Synopsis
- - The study investigated how osteoclast inhibitors alendronate (ALN) and denosumab (DMAB) affect fracture healing by analyzing their effects on fracture callus in mice with induced bone fractures.
- - Results indicated that DMAB treatment nearly eliminated TRACP 5b levels, while ALN reduced it only by about 25%, with both treatments improving the mechanical properties of the healed bones after 42 days compared to control groups.
- - Histological evaluations showed that both treatments resulted in more unresorbed cartilage compared to controls, but did not compromise the bone strength and stiffness of the healing fractures, suggesting that osteoclast inhibition can be beneficial during fracture healing.
