Publications by authors named "Daniel J Kojis"
Background And Objectives: Neurotrophic factors (NTFs) play an important role in Alzheimer disease (AD) pathophysiology. Brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF) are important NTFs. However, a direct link of BDNF and VEGF circulating levels with in vivo measures of amyloid-β (Aβ) and tau burden remains to be elucidated.
View Article and Find Full Text PDFBackground And Objectives: Higher YKL-40 levels in the CSF are a known biomarker of brain inflammation. We explored the utility of plasma YKL-40 as a biomarker for accelerated brain aging and dementia risk.
Methods: We performed cross-sectional and prospective analyses of 4 community-based cohorts in the United States or Europe: the Age, Gene/Environment Susceptibility-Reykjavik Study, Atherosclerosis Risk in the Communities study, Coronary Artery Risk Development in Young Adults study, and Framingham Heart Study (FHS).
Article Synopsis
- The study aimed to analyze the relationship between self-reported sleep duration and neuroimaging markers related to Alzheimer's disease, focusing on amyloid, tau, neurodegeneration, and vascular factors.
- It utilized data from participants in the Framingham Heart Study who underwent various imaging tests, assessing their sleep duration categorized into short, average, and long at two different times: at the testing point and approximately 13 years prior.
- The results indicated no significant direct link between sleep duration and neuroimaging measures; however, long-term changes to longer sleep duration were associated with increased brain damage markers, while consistently long sleepers showed lower levels of brain damage compared to those with average sleep duration.
Importance: Cognitive resilience refers to the general capacity of cognitive processes to be less susceptible to differences in brain structure from age- and disease-related changes. Studies suggest that supportive social networks reduce Alzheimer disease and related disorder (ADRD) risk by enhancing cognitive resilience, but data on specific social support mechanisms are sparse.
Objective: To examine the association of individual forms of social support with a global neuroanatomical measure of early ADRD vulnerability and cognition.