Publications by authors named "Daniel J Gardner"
Background: Silicone breast implants with smooth outer shells are associated with higher rates of capsular contracture, whereas textured implants have been linked to the development of breast implant-associated anaplastic large cell lymphoma. By assessing the gene expression profile of fibrous capsules formed in response to smooth and textured implants, insight into the development of breast implant-associated abnormalities can be gained.
Methods: Miniature smooth or textured silicone implants were surgically inserted into female rats ( n = 10) and harvested for the surrounding capsules at postoperative week 6.
Article Synopsis
- Soft tissue sarcomas, which are a rare type of malignant tumor making up about 1% of adult cancers, primarily affect the lower extremities.
- Treatment often involves surgery, such as wide local resection, sometimes requiring reconstruction by a plastic surgeon, and can include amputation in severe cases.
- A study of 127 patients revealed that 43.3% experienced wound complications, with those complications linked to higher rates of immediate reconstruction and slightly higher rates of neoadjuvant radiation therapy.
Mesenchymal Stromal Cells Isolated from Irradiated Human Skin Have Diminished Capacity for Proliferation, Differentiation, Colony Formation, and Paracrine Stimulation.
Stem Cells Transl Med
September 2019
Ionizing radiation, commonly used in the treatment of solid tumors, has unintended but deleterious effects on overlying skin and is associated with chronic nonhealing wounds. Skin-derived mesenchymal stromal cells (SMSCs) are a pluripotent population of cells that are critically involved in skin homeostasis and wound healing. The aim of this study was to isolate and functionally characterize SMSCs from human skin that was previously irradiated as part of neoadjuvant or adjuvant cancer therapy.
View Article and Find Full Text PDFDigit replantation affords the opportunity to restore hand function following amputation. To date, however, few studies have evaluated functional outcomes following replantation. Therefore, it was the objective of this study to perform a meta-analysis to better characterize the predictors of hand function.
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- - Carpometacarpal joint osteoarthritis impacts 8-12% of people, and while surgery helps 78% of those not responding to other treatments, there's no clear agreement on the best surgical method; recent studies have looked at using acellular dermal matrices instead of traditional implants.
- - In a study using New Zealand rabbits, researchers compared implants of acellular dermal matrix and autologous tissue after removing the lunate carpal bones, analyzing the results through various histological techniques over 12 weeks.
- - Results showed that acellular dermal matrices led to significant increases in blood vessel formation in both the joint and subcutaneous areas, while autologous tissue did not show similar vascular growth; overall,
Wound healing is significantly delayed in irradiated skin. To better understand global changes in protein expression after radiation, we utilized a reverse phase protein array (RPPA) to identify significant changes in paired samples of normal and irradiated human skin. Of the 210 proteins studied, fibronectin was the most significantly and consistently downregulated in radiation-damaged skin.
View Article and Find Full Text PDFChronic wounds affect over 4 million individuals and pose a significant burden to the US healthcare system. Diabetes, venous stasis, radiation or paralysis are common risk factors for chronic wounds. Unfortunately, the current standard of care (SOC) has a high relapse rate and these wounds continue to adversely affect patients' quality of life.
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