Electroconvulsive therapy for the acute management of severe agitation in dementia (ECT-AD): A modified study protocol.

Objective: This study began as a single-blind randomized controlled trial (RCT) to investigate the efficacy and safety of electroconvulsive therapy (ECT) for severe treatment-refractory agitation in advanced dementia. The aims are to assess agitation reduction using the Cohen-Mansfield Agitation Inventory (CMAI), evaluate tolerability and safety outcomes, and explore the long-term stability of agitation reduction and global functioning. Due to challenges encountered during implementation, including recruitment obstacles and operational difficulties, the study design was modified to an open-label format and other protocol amendments were implemented.

Evaluation of harvesting urban water resources for sustainable water management: Case study in Filton Airfield, UK.

Filton Airfield in the UK is a new community under development aiming to become self-sufficient in its water supply toward a circular economy. Urban water management strategies, water demand minimization, urban resource reuse, and wastewater discharge minimization, can improve the urban circular economy. Understanding the practical impacts of those strategies is crucial for a new development area like Filton.

Optimal storage sizing for indoor arena rainwater harvesting: Hydraulic simulation and economic assessment.

This study demonstrates a large roof (30,000 m) rainwater harvesting (RWH) system in an indoor arena by considering three water demand scenarios (toilet flushing, irrigation and combined demand) via hydraulic and economic assessments. The water saving efficiency (WSE) of the RWH system for each scenario was estimated by a simulation model using historical daily rainfall data (1968-2018). Depending on the water demand, the WSE was found to be independent of tank size when the tank size exceeded 1000 m.

A Latent Class Analysis of Perceived Neighborhood Conditions Associated with Mental Disorders Among Children in the United States.

The current study examined the association between perceived neighborhood conditions and common childhood mental disorders in a nationally representative sample of children in the U.S. The data were derived from the 2017 National Survey of Children's Health, including American children aged 6-17 years (N = 15,438).

A temporal relationship between nonmedical opioid Use and major depression in the U.S.: A Prospective study from the National Epidemiological Survey on Alcohol and Related Conditions.

Background: Given the existing strong cross-sectional relationship between nonmedical opioid use (NMOU) and major depressive disorder (MDD), this study focused on the temporal relationship between NMOU and major depression.

Methods: Data sources were derived from Wave 1 and Wave 2 of the National Epidemiological Survey on Alcohol and Related Conditions. Logistic regression was applied to predicted NMOU at the follow-up survey based on baseline MDD diagnosis and symptoms of MDD among the sample without lifetime NMOU at baseline (N=32,982).

Retinal Dystrophy and Optic Nerve Pathology in the Mouse Model of Mucolipidosis IV.

Mucolipidosis IV is a debilitating developmental lysosomal storage disorder characterized by severe neuromotor retardation and progressive loss of vision, leading to blindness by the second decade of life. Mucolipidosis IV is caused by loss-of-function mutations in the MCOLN1 gene, which encodes the transient receptor potential channel protein mucolipin-1. Ophthalmic pathology in patients includes corneal haze and progressive retinal and optic nerve atrophy.

Impaired myelination and reduced brain ferric iron in the mouse model of mucolipidosis IV.

Mucolipidosis type IV (MLIV) is a lysosomal storage disease caused by mutations in the MCOLN1 gene, which encodes the lysosomal transient receptor potential ion channel mucolipin-1 (TRPML1). MLIV causes impaired motor and cognitive development, progressive loss of vision and gastric achlorhydria. How loss of TRPML1 leads to severe psychomotor retardation is currently unknown, and there is no therapy for MLIV.