Higher doses of bisphosphonates further improve bone mass, architecture, and strength but not the tissue material properties in aged rats.

We report the results of a series of experiments designed to determine the effects of ibandronate (Ibn) and risedronate (Ris) on a number of bone quality parameters in aged osteopenic rats to explain how bone material and bone mass may be affected by the dose of bisphosphonates (BP) and contribute to their anti-fracture efficacy. Eighteen-month old female rats underwent either ovariectomy or sham surgery. The ovariectomized (OVX) groups were left untreated for 2 months to develop osteopenia.

Precision of time devices used by prehospital providers.

Background: As many medical, medicolegal, and research interests have become more time-dependent, increased weight should be placed on the precision of time documentation and timing devices. Studies have previously documented poor synchronization of timing devices in the medical setting. Objective.