Value of ¹⁸F-FDG uptake on PET/CT and CEA level to predict epidermal growth factor receptor mutations in pulmonary adenocarcinoma.

Purpose: The identification of the mutation status of the epidermal growth factor receptor (EGFR) is important for the optimization of treatment in patients with pulmonary adenocarcinoma. The acquisition of adequate tissues for EGFR mutational analysis is sometimes not feasible, especially in advanced-stage patients. The aim of this study was to predict EGFR mutation status in patients with pulmonary adenocarcinoma based on (18)F-fluorodeoxyglucose (FDG) uptake and imaging features in positron emission tomography/computed tomography (PET/CT), as well as on the serum carcinoembryonic antigen (CEA) level.

Experience of low-dose aminophylline use to relieve minor adverse effects of dipyridamole in patients undergoing stress myocardial perfusion imaging.

Background: Intravenous administration of aminophylline is widely adopted to reverse dipyridamole-related adverse effects (AEs) during stress myocardial perfusion imaging (MPI). The study aimed to investigate the efficacy of lower-dose aminophylline to relieve minor AEs.

Methods: 2,250 consecutive patients undergoing dipyridamole-stressed MPI were enrolled.

Conversion from FDG-negative to -positive during follow-up in a rare case of pulmonary lymphoepithelioma-like carcinoma.

A female patient aged 75 years presented with an incidental pulmonary nodule without FDG uptake when undergoing FDG PET/CT. Without obtaining histologic diagnosis, the follow-up FDG PET/CT 2 years later demonstrated intense FDG avidity within previously FDG-negative tumor. After surgery, the pathologic diagnosis is pulmonary lymphoepithelioma-like carcinoma (LELC).

Tumoral calcinosis demonstrated on Tc-99m sestamibi scintigraphy.

A 61-year-old uremic male under hemodialysis underwent Tc-99m sestamibi scintigraphy due to suspicious secondary hyperparathyroidism. The images showed increased uptake in the right forearm, left shoulder, right knee and, to a lesser extent, in the left hip and the right thigh. Subsequent Tc-99m MDP bone scintigraphy and x-ray studies revealed intense extraosseous uptake and calcified masses in areas corresponding to those found in Tc-99m sestamibi scintigraphy, suggesting tumoral calcinoses.

Imaging of metastatic pulmonary tumors following NIS gene transfer using single photon emission computed tomography.

The Na+/I- symporter (NIS) is a membrane glycoprotein that facilitates the uptake of iodine into thyroid follicular cells. Recently, we and others have demonstrated the feasibility of imaging subcutaneous xenografts expressing exogenous NIS, suggesting that NIS may serve as an imaging reporter gene to monitor vector delivery and therapeutic gene expression. In this study, we established NIS-expressing pulmonary tumors in nude mice to investigate the minimal tumor size required for in vivo detection of pulmonary tumors by single photon emission computed tomography (SPECT) with pinhole collimation.