Publications by authors named "Daniel Gomes da Costa"
Plasmodium replicates within the liver prior to reaching the bloodstream and infecting red blood cells. Because clinical manifestations of malaria only arise during the blood stage of infection, a perception exists that liver infection does not impact disease pathology. By developing a murine model where the liver and blood stages of infection are uncoupled, we showed that the integration of signals from both stages dictated mortality outcomes.
View Article and Find Full Text PDFArticle Synopsis
- Maternal innate-like lymphocytes, particularly γδ T cells, play a crucial role in shaping the immune response of offspring during development, influencing inflammation and immune cell types.
- Mice born to mothers lacking γδ T cells show heightened inflammation and a type 2 immune response, particularly after helminth infections, due to changes in their gut microbiota and levels of short-chain fatty acids (SCFAs).
- Supplementing SCFAs can reduce inflammation and improve lung immunity in these offspring, highlighting the interplay between maternal immune cells, gut microbiota, and neonatal immune development.