Publications by authors named "Daniel Gerber"

Article Synopsis
  • The Carpathian Basin experienced significant demographic changes during the Early Medieval period, influenced by Avar rule for about 250 years and the arrival of early Hungarians in the late 9th century CE.
  • This study analyzes 296 ancient genetic samples from Western Hungary, providing insights into the population structure and dynamics between the 5th and 11th centuries CE, focusing on specific microregions.
  • The research uncovers distinct historical developments in Transdanubia, emphasizing the complex interactions and genetic integration among Hun, Avar, and Hungarian groups during and after the conquest period.
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We present a method for improving the amplitude and angular error of inductive position sensors, by advancing the design of receiver coil systems with multiple windings on two layers of a printed circuit board. Multiple phase-shifted windings are connected in series, resulting in an increased amplitude of the induced voltage while decreasing the angular error of the sensor. The amplitude increase for a specific number of windings can be predicted in closed form.

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Urinary incontinence is a common complication following radical prostatectomy, as the surgery disturbs critical anatomical structures. This study explored how pudendal nerve (PN) injury affects urinary continence in male rats. In an acute study, leak point pressure (LPP) and external urethral sphincter electromyography (EMG) were performed on six male rats with an intact urethra, the urethra exposed (UE), the PN exposed (NE), and after PN transection (PNT).

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  • Previous studies show variability in cardiac intensive care unit (CICU) length of stay (LOS), but lacked detailed risk assessments upon admission, prompting a new evaluation of LOS and its link to in-hospital mortality across different hospitals.
  • Analysis of 22,862 admissions from 35 CICUs over five years revealed a median CICU LOS of 2.2 days, with longer stays associated with younger patients having more comorbidities and higher mortality rates across tertiles of LOS.
  • The study concluded that significant differences in CICU LOS exist and that longer LOS correlates with increased risk of in-hospital mortality, suggesting improvements in CICU planning and resource use are necessary.
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  • The study aimed to evaluate the effectiveness of the IABP-SHOCK II risk score in predicting in-hospital mortality in cardiogenic shock (CS) patients from a North American cohort, comparing its performance to its original European context.
  • The analysis included 5,340 admissions for CS across 35 medical centers, revealing that the IABP-SHOCK II score effectively identified different risk levels of mortality in both AMI-related and non-AMI-related CS patients.
  • Overall, while the risk score demonstrated some predictive capability for in-hospital mortality in various CS types, its correlation with other mortality assessment tools was only moderate, indicating room for improvement in risk stratification methods.
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  • * A study analyzed data from nearly 18,000 CICU admissions across 34 hospitals to assess the use of CCRx and its association with in-hospital survival, finding disparities in patient acuity and therapy utilization among hospitals.
  • * The findings revealed that patients in hospitals with higher CCRx usage tended to have more severe conditions and higher comorbidity rates; however, adjusted mortality rates did not significantly differ based on CCRx levels, implying patient factors primarily influence therapy variations.
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Coagulopathy is common in patients undergoing thoracic aortic repair for Stanford type A aortic dissection. Non-critical administration of blood products may adversely affect the outcome. It is therefore important to be familiar with the pathologic conditions that lead to coagulopathy in complex cardiac surgery.

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  • - In Bangladesh, a preventive chemotherapy program for soil-transmitted helminth (STH) infections in school-age children has been in effect since 2008, aiming to reduce infection rates through targeted treatment and evaluation of its geographical spread and risk factors from 2017 to 2020.
  • - Researchers used advanced Bayesian geostatistical models to analyze STH prevalence data across various districts, taking into account multiple predictors and estimating treatment needs based on a gridded population dataset, resulting in specific antimicrobial dosage requirements for different risk groups.
  • - The study found varying prevalence rates for specific STH species and highlighted significant associations with household sanitation and environmental factors, estimating that approximately 30.5 million treatment doses are needed yearly for Bangl
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  • Invasive haemodynamic assessment using a pulmonary artery catheter is important for managing patients with cardiogenic shock (CS) and understanding their prognosis.
  • A study analyzed data from a multicenter registry involving patients with CS to find relationships between their haemodynamic parameters and outcomes like in-hospital mortality and end-organ dysfunction.
  • Key findings indicated that lower mean arterial pressure, lower systolic blood pressure, and other specific haemodynamic metrics were linked to worse outcomes and higher serum lactate levels, suggesting severe circulatory issues.
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Background: There are no current recommendations for oxygen titration in patients with stable coronary artery disease. This study investigates the effect of iatrogenic hyperoxia on cardiac function in patients with coronary artery disease undergoing general anaesthesia.

Methods: Patients scheduled for elective coronary artery bypass graft surgery were prospectively recruited into this randomised crossover clinical trial.

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In this study, we report 21 ancient shotgun genomes from present-day Western Hungary, from previously understudied Late Copper Age Baden, and Bronze Age Somogyvár-Vinkovci, Kisapostag, and Encrusted Pottery archeological cultures (3,530-1,620 cal Bce). Our results indicate the presence of high steppe ancestry in the Somogyvár-Vinkovci culture. They were then replaced by the Kisapostag group, who exhibit an outstandingly high (up to ∼47%) Mesolithic hunter-gatherer ancestry, despite this component being thought to be highly diluted by the time of the Early Bronze Age.

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  • The study presents genetic data from the Székely ethnic group in southeast Transylvania, including 115 whole mitochondrial genomes and 92 Y-chromosomal profiles.
  • The research is notable for providing the first complete DNA sequences and STR profiles for this region, offering insights into local ancestry dating back to the 12th century.
  • The findings suggest that the Székelys have primarily local ancestry with minimal mixing from neighboring groups and support a historical link to ancient populations from significant migration periods.
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Background: Cardiac arrest (CA) is a common reason for admission to the cardiac intensive care unit (CICU), though the relative burden of morbidity, mortality, and resource use between admissions with in-hospital (IH) and out-of-hospital (OH) CA is unknown. We compared characteristics, care patterns, and outcomes of admissions to contemporary CICUs after IHCA or OHCA.

Methods: The Critical Care Cardiology Trials Network is a multicenter network of tertiary CICUs in the US and Canada.

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Red blood cell salvage plays an important role in reducing the use of allogeneic blood transfusion during cardiac surgery. While there is consensus as to the benefit of employing cell salvage systems, there are no clear recommendations on the anticoagulant used for salvaged blood. In eight patients undergoing elective cardiac surgery at our university hospital's cardiovascular center, the authors describe hemodynamic effects of salvaged autologous blood transfusion when either unfractionated heparin or acid citrate dextrose formula A was used as the anticoagulant.

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Efficient myelination supports nerve conduction and axonal health throughout life. In the central nervous system, oligodendrocytes (OLs) carry out this demanding anabolic duty in part through biosynthetic pathways controlled by mTOR. We identify Ral GTPases as critical regulators of mouse spinal cord myelination and myelin maintenance.

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Most of the early Hungarian tribes originated from the Volga-Kama and South-Ural regions, where they were composed of a mixed population based on historical, philological and archaeological data. We present here the uniparental genetic makeup of the mediaeval era of these regions that served as a melting pot for ethnic groups with different linguistic and historical backgrounds. Representing diverse cultural contexts, the new genetic data originate from ancient proto-Ob-Ugric people from Western Siberia (6th-13th century), the pre-Conquest period and subsisting Hungarians from the Volga-Ural region (6th-14th century) and their neighbours.

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Article Synopsis
  • The domestication of horses significantly changed mobility and warfare, but modern breeds do not trace back to the earliest domestic horses found in Central Asia around 3500 BC.
  • Research reestablishes the Western Eurasian steppes, particularly the lower Volga-Don area, as the origin of modern domestic horses, based on genetic analysis from 273 ancient horse genomes.
  • The study finds that the spread of modern domestic horses around 2000 BC coincided with the emergence of equestrian cultures, refuting the idea that horseback riding was linked to the expansion of Yamnaya pastoralists in Europe.
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  • Heart failure-related cardiogenic shock (HF-CS) is becoming more common in cardiac intensive care units, and this study focused on whether the chronicity of heart failure affects clinical profiles in these patients.
  • Researchers analyzed data from 28 centers involving 1,405 admissions for HF-CS between 2017-2020, finding that 26.3% were classified as de novo HF-CS and 73.7% as acute-on-chronic HF-CS.
  • Patients with de novo HF-CS exhibited fewer comorbidities but had more severe shock symptoms and a higher risk of in-hospital mortality compared to those with acute-on-chronic HF-CS, indicating the need for further research on the underlying mechanisms and treatment responses in these
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Background: Single-center studies suggest that implementation of multidisciplinary cardiogenic shock (CS) teams is associated with improved CS survival.

Objectives: The aim was to characterize practice patterns and outcomes in the management of CS across multiple centers with versus without shock teams.

Methods: The Critical Care Cardiology Trials Network is a multicenter network of cardiac intensive care units (CICUs) in North America.

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Objectives: To determine the impact of prior pelvic radiation therapy (XRT) on outcomes following radical cystectomy (RC) for bladder cancer.

Materials And Methods: We performed a retrospective review comparing patients with bladder cancer requiring RC and prior history of XRT for prostate cancer to those undergoing RC without XRT history at our institution from 2011-2018. Propensity score matching was performed with the following variables: age, chronic kidney disease, nutritional deficiency, neoadjuvant chemotherapy use, Charlson comorbidity index, surgical approach, urinary diversion type, and pathologic T-stage.

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Perioperative visual loss is a rare but severe complication after surgery in prone position. One of several mechanisms is direct ophthalmic compression. This can be avoided through optimal positioning and padding of the head, but position and integrity of the eyes need to be checked at regular intervals.

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Objectives: To compare oncologic endpoints between open radical cystectomy (ORC) and robotic-assisted radical cystectomy with extracorporeal urinary diversion (eRARC) or intracorporeal urinary diversion (iRARC).

Materials And Methods: Retrospective review of all patients undergoing curative-intent radical cystectomy with urinary diversion for urothelial bladder cancer at a single-institution from 2010-2018. Primary outcomes included recurrence location and rates, recurrence-free (RFS) and overall survival (OS).

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