Microwave-Assisted Synthesis and Properties of Novel Hexaazatrinaphthylene Dendritic Scaffolds.

A novel family of water-soluble π-conjugated hexaazatrinaphthylenes-based dendritic architectures constructed by hexaketocyclohexane and 1,2,4,5-benzenetetramine units is developed in a microwave-assisted organic synthesis (MAOS) approach. The structures and purity of these compounds are verified by H and C-NMR, MALDI-TOF MS, UV-vis, elemental analysis, DSC, AFM, STM and cyclic voltammetry.

In vitro activities of hexaazatrinaphthylenes against Leishmania spp.

The in vitro activity of a novel group of compounds, hexaazatrinaphthylene derivatives, against two species of Leishmania is described in this study. These compounds showed a significant dose-dependent inhibition effect on the proliferation of the parasites, with 50% inhibitory concentrations (IC(50)s) ranging from 1.23 to 25.

Novel organogelators based on amine-derived hexaazatrinaphthylene.

Novel C(3)-symmetrical heteroaromatic hexaazatrinaphthylene (HATNA) gelators symmetrically end-substituted with pendant aromatic and aliphatic amines were synthesized. Some of these π-conjugated structures induce self-assembly, forming fibers able to gelate solvents of different polarity at low wt% as demonstrated by spectroscopic and microscopic techniques.

Instantaneous low temperature gelation by a multicomponent organogelator liquid system based on ammonium salts.

A new synergistic multicomponent organogelator liquid system (MOGLS) was discovered during the standard protocol of tartaric acid-mediated racemic resolution of (+/-)- trans-1,2-diaminocyclohexane. The MOGLS is formed by a 0.126 M methanolic solution of (1 R,2 R)-(+)-1,2-diaminocyclohexane L-tartrate and 1 equiv of concentrated hydrochloric acid.