CSC01 shows promise as a potential inhibitor of the oncogenic G13D mutant of KRAS: an in silico approach.

About 30% of malignant tumors include KRAS mutations, which are frequently required for the development and maintenance of malignancies. KRAS is now a top-priority cancer target as a result. After years of research, it is now understood that the oncogenic KRAS-G12C can be targeted.

Modulation of immunological responses by aqueous extract of Datura stramonium L. seeds on cyclophosphamide-induced immunosuppression in Wistar rats.

Background: Datura stramonium L. (Solanaceae) is used traditionally in west Africa to treat asthma, epilepsy, rheumatoid arthritis, filariasis microbial infections and conjunctivitis. This study investigated the immunomodulatory effects of aqueous seed extract of D.

Ethyl acetate fraction of Fagara zanthoxyloides root-bark possess antidiabetic property against alloxan-induced diabetes and its complications in Wistar rat model.

Ethnopharmacological Relevance: Fagara zanthoxyloides Lam., an African traditional medicinal plant, is used for treatment of malaria and diabetes.

Aim: To investigate the antidiabetic property of ethyl acetate fraction of F.

UPLC-PDA-ESI-QTOF-MS/MS fingerprint of purified flavonoid enriched fraction of ; antioxidant properties, anticholinesterase activity and in studies.

Context: (Lam.) Oken (Crassulaceae) is used traditionally to treat many ailments.

Objectives: This study characterizes the constituents of flavonoid-rich fraction (BPFRF) and investigates their antioxidant and anticholinesterase activity using and approaches.

Flavonoid-rich fraction of leaves alleviates hepatotoxicity induced by carbon tetrachloride in Wistar rats.

P. Beauv. (Icacinaceae) is a good source of natural antioxidants, having the potential to protect against oxidative stress-related diseases and complications.

Bioassay-guided fractionation, phospholipase A-inhibitory activity and structure elucidation of compounds from leaves of .

Context: Harms (Rubiaceae) is used traditionally in Nigeria for the treatment of snake bites. Snake venom contains phospholipase A (PLA) which plays a key role in causing inflammation and pain.

Objective: To assess the anti-inflammatory effect of the methanol extract of (MESM) leaves through the inhibition of PLA and investigate the compounds responsible for the effect.

High resolution UPLC-PDA-QTOF-ESI-MS/MS analysis of the flavonoid-rich fraction of leaves, and evaluation of its renal and cardiac function effects.

P. Beauv. (Icacinaceae) is a traditional Nigerian medicinal plant used for treatment of ulcers, diarrhea, parasitic infections and diabetes.