Publications by authors named "Daniel E Martinez Pinerez"
Biology (Basel)
October 2024
Article Synopsis
- The study explores how dyslipidemia, specifically oxidized LDL (OxLDL), affects the proliferation of prostatic stromal cells and the release of extracellular vesicles (EVs), which are linked to Benign Prostatic Hyperplasia (BPH).
- Mice were given a high-fat diet and human prostatic stromal cells were exposed to OxLDL, revealing that dyslipidemic conditions promote increased cell growth and the secretion of EVs that further stimulate this growth.
- Treatment with metformin was found to significantly reduce OxLDL-induced cell proliferation, suggesting it could be a potential therapeutic option for managing BPH by targeting the underlying mechanisms associated with dyslipidemia.
