Obstructive sleep apnea and the risk of sudden cardiac death: a longitudinal study of 10,701 adults.

Objectives: This study sought to identify the risk of sudden cardiac death (SCD) associated with obstructive sleep apnea (OSA).

Background: Risk stratification for SCD, a major cause of mortality, is difficult. OSA is linked to cardiovascular disease and arrhythmias and has been shown to increase the risk of nocturnal SCD.

Metabolic syndrome and risk of incident cardiovascular events and death: a systematic review and meta-analysis of longitudinal studies.

Objectives: The purpose of this research was to assess the association between the metabolic syndrome (MetSyn) and cardiovascular events and mortality by meta-analyses of longitudinal studies.

Background: Controversy exists regarding the cardiovascular risk associated with MetSyn.

Methods: We searched electronic reference databases through March 2005, studies that referenced Reaven's seminal article, abstracts presented at meetings in 2003 to 2004, and queried experts.

Day-night pattern of sudden death in obstructive sleep apnea.

Background: The risk of sudden death from cardiac causes in the general population peaks from 6 a.m. to noon and has a nadir from midnight to 6 a.

Tumorigenic mutations in VHL disrupt folding in vivo by interfering with chaperonin binding.

The eukaryotic chaperonin TRiC/CCT mediates folding of an essential subset of newly synthesized proteins, including the tumor suppressor VHL. Here we show that chaperonin binding is specified by two short hydrophobic beta strands in VHL that, upon folding, become buried within the native structure. These TRiC binding determinants are disrupted by tumor-causing point mutations that interfere with chaperonin association and lead to misfolding.