Functionalized calcium carbonate as a novel pharmaceutical excipient for the preparation of orally dispersible tablets.

Purpose: To overcome the limitation of insufficient hardness during the production of rapidly disintegrating orally dispersible tablets (ODTs). Furthermore, we investigated the properties and usefulness of functionalized calcium carbonate (FCC) as a new pharmaceutical excipient for the production of ODTs.

Methods: A highly sensitive tensiometer-based method was developed to measure kinetics of weight loss during tablet disintegration.