Publications by authors named "Daniel Dreuil"
Article Synopsis
- This study explored the effectiveness of the BNT162b2 booster vaccine on neutralizing antibodies and T cell responses in healthcare workers against the Omicron sublineages BA.1 and BA.2, before and three months after vaccination.
- Results showed that before the booster, a small percentage of participants had measurable neutralizing activity, but by three months post-booster, nearly all had developed strong antibody responses against Delta and Omicron variants, although the levels were lower for BA.1 and BA.2 than for Delta.
- Participants with recent SARS-CoV-2 infections maintained stable antibody levels, while those without infections experienced a decrease in neutralizing antibody titres over the three-month period.
Immunogenicity of BNT162b2 vaccine booster against SARS-CoV-2 Delta and Omicron variants in nursing home residents: A prospective observational study in older adults aged from 68 to 98 years.
Lancet Reg Health Eur
June 2022
Background: The present study aimed to evaluate the persistent immunogenicity offered by a third dose of BNT162b2 against Delta and Omicron variants, in nursing home (NH) residents.
Methods: In this monocenter prospective observational study, anti-spike IgG levels, S1 domain reactive T cell counts, serum neutralizing antibody titers against Delta and Omicron variants were compared before and up to three months after the BNT162b2 booster dose, in NH residents without COVID-19 (COVID-19 naive) or with COVID-19 prior to initial vaccination (COVID-19 recovered).
Findings: 106 NH residents (median [interquartile range] age: 86·5 [81;91] years) were included.
Long-term care facility (LTCF) older residents display physiological alterations of cellular and humoral immunity that affect vaccine responses. Preliminary reports suggested a low early postvaccination antibody response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The aim of this study was to focus on the specific T-cell response.
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