Publications by authors named "Daniel Ditterich"
Introduction: The transmembrane channel protein DOG1 (Discovered on GIST1) is normally expressed in the gastrointestinal interstitial cells of Cajal and also in gastrointestinal stroma tumors arising from these cells. However, there is also evidence for a relevant role of DOG1 expression in colorectal cancers. This study was undertaken to search for associations between DOG1 expression and colon cancer phenotype and key molecular alterations.
View Article and Find Full Text PDFBackground: Immune checkpoint-inhibitors targeting the PD-1/PD-L1 system are FDA approved in microsatellite instable (MSI) or mismatch repair deficient (dMMR) colorectal cancer (CRC). PD-L1 expression is tightly linked to features connected to immune checkpoint inhibitor response, but studies on large subsets of cancers analyzing the correlation between different status of MSI/dMMR, tumor infiltrating lymphocytes and PD-L1 expression are still lacking.
Methods: More than 1800 CRC were analyzed for PD-L1 by immunohistochemistry in a tissue microarray format.
Article Synopsis
- - Mucin 5AC (MUC5AC) is a type of gel-forming protein found in certain epithelial tissues and is present in higher amounts in colorectal cancers, with the study analyzing 1,812 colorectal cancer samples.
- - MUC5AC expression was observed in 15.7% of analyzable cancers, showing a significant decrease from the cecum to the rectum, and was closely linked to a condition called mismatch repair deficiency (dMMR).
- - The study concluded that MUC5AC expression is strongly associated with cancer localized in the proximal colon and dMMR status but does not correlate with the overall aggressiveness of colorectal cancer.