Publications by authors named "Daniel DeRoche"
Liver fibrosis is a common pathway shared by all forms of progressive chronic liver disease. There is an unmet clinical need for noninvasive imaging tools to diagnose and stage fibrosis, which presently relies heavily on percutaneous liver biopsy. Here we explored the feasibility of using a novel type I collagen-targeted manganese (Mn)-based MRI probe, Mn-CBP20, for liver fibrosis imaging.
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- Five amphiphilic, anionic Mn(II) complexes were created to be used as contrast agents for liver MRI, targeting specific transporters in the body.
- The complexes were synthesized in three steps from a common chelator, showing relaxivity values between 2.3 and 3.0 mM s in a buffered saline solution.
- In vivo studies in mice and in vitro assays with human cell lines demonstrated effective uptake of these complexes, suggesting they could be adapted for various MRI applications.