Publications by authors named "Daniel Davila Williams"
Article Synopsis
- New-onset refractory status epilepticus (NORSE) is a serious condition that can cause significant disability, often not responding well to standard treatments.
- An 11-year-old girl with anti-GAD 65 encephalitis who experienced NORSE showed minimal improvement with regular anti-seizure medications and first-line therapies.
- After receiving intrathecal dexamethasone (IT-DEX) along with rituximab, her neuroinflammation decreased, seizure frequency dropped, and she could reduce anesthesia, suggesting IT-DEX could be beneficial early on for various causes of refractory status epilepticus.
Pediatric pial arteriovenous shunts in the brain and spine are challenging to understand because of low incidence, variable presentation, and associations with genetic syndromes. What is known about their natural history comes from reviews of small series. To better understand the natural history and role for intervention, two cases are presented followed by a review of the literature.
View Article and Find Full Text PDFUp to more than half of previously healthy children presenting with their first arterial ischemic stroke have a cerebral arteriopathy. Cerebral arteriopathies during childhood can be congenital, reflecting abnormal vessel development, or acquired when caused by disruption of vascular homeostasis. Distinguishing different types of cerebral arteriopathies in children can be challenging but of great clinical value as they may dictate different disease and treatment courses, and clinical and radiologic outcomes.
View Article and Find Full Text PDFElectrical status epilepticus in sleep (ESES) is a pattern of continuous spikes seen in electroencephalography (EEG) and may be associated with neuropsychological deficits in children. This EEG pattern has not previously been reported in older adults. In this case report, a 66-year-old woman with post-traumatic epilepsy presented to the emergency department following a breakthrough seizure.
View Article and Find Full Text PDFPurpose Of Review: This review provides guidance for acute spinal cord injury (SCI) management through an analytical assessment of the most recent evidence on therapies available for treating SCI, including newer therapies under investigation. We present an approach to the SCI patient starting at presentation to acute rehabilitation and prognostication, with additional emphasis on the pediatric population when evidence is available.
Recent Findings: Further studies since the Surgical Timing in Acute Spinal Cord Injury Study (STASCIS) demonstrated a potential functional outcome benefit with ultra-early surgical intervention ≤ 8 h post-SCI.