Bilateral negative sentinel nodes accurately predict absence of lymph node metastasis in early cervical cancer: results of the SENTICOL study.

Purpose: Sentinel lymph node (SLN) biopsy may be used to target lymph node metastases in patients with early cervical cancer. Whether SLN biopsy only is acceptable in the staging and surgical management of early cervical cancer remains unknown. This prospective multicenter study (SENTICOL [Ganglion Sentinelle dans le Cancer du Col]) assessed the sensitivity and negative predictive value (NPV) of SLN biopsy.

Oncological safety of laparoscopic-assisted vaginal radical trachelectomy (LARVT or Dargent's operation): a comparative study with laparoscopic-assisted vaginal radical hysterectomy (LARVH).

Objective: The aim of our study was to compare the results of radical trachelectomy (LARVT or Dargent's operation) to radical vaginal hysterectomy (LARVH) in terms of intraoperative and postoperative morbidity and mainly in terms of risk of tumor recurrence. Each technique is associated with laparoscopic pelvic lymph node dissection. Our objective was to know if performing radical trachelectomy in order to preserve the fertility of a young patient with an early cervical cancer is associated or not with an increased risk of operative morbidity or tumor recurrence.

Clinical significance of lympho vascular space involvement and lymph node micrometastases in early-stage cervical cancer: a retrospective case-control surgico-pathological study.

Objective: Several studies have shown that lympho vascular space involvement (LVSI) and lymph node micrometastases (LNmM) may be risk factors for recurrence in early-stage cervical cancer with no apparent lymph node metastases. We performed a retrospective case-control study to reassess whether the presence of lymph node micrometastases and LVSI is predictive of subsequent recurrence following surgical resection of early-stage cervical cancer.

Methods: In a series of 292 patients diagnosed with early cervical cancer and treated by the same surgical procedure (laparoscopic-vaginal radical hysterectomy) during the same time period, two paired series were selected.

Laparoscopic lymphadenectomy and sentinel node biopsy in uterine cancer.

This article discusses laparoscopic lymphadenectomy and sentinel node biopsy in uterine cancer.

[Clinical practice guidelines: Standards, Options and Recommendations for first line medical treatment of patients with ovarian neoplasms (summary report)].

Context: The "Standards, Options and Recommendations" (SOR) project, which started in 1993, is a collaboration between the French Federation of Cancer Centers (FNCLCC), the 20 French Regional Cancer Centers, and specialists from French public universities, general hospitals and private clinics. The main objective is the development of clinical practice guidelines to improve the quality of health care and the outcome of cancer patients.

Objective: To update clinical practice guidelines for first line medical treatment of patients with ovarian neoplasms in collaboration with the French Society for Gynaecologica Oncology.

Pregnancy after trachelectomy: a high-risk condition of preterm delivery. Report of a case and review of the literature.

Background: Trachelectomy is a conservative but locally radical procedure associated with a high risk of preterm delivery.

Case: A 28-year-old patient with cervical cancer FIGO stage IB1 was treated with laparoscopic pelvic lymphadenectomy followed by trachelectomy. Three years later, she conceived spontaneously.

Sentinel lymph node biopsy is not accurate in predicting lymph node status for patients with cervical carcinoma.

Background: The authors evaluated the accuracy of sentinel lymph node biopsy in predicting lymph node status for patients with early cervical carcinoma. In particular, the authors set out to determine the false-negative rate associated with sentinel lymph node biopsy in this setting.

Methods: Twenty-nine consecutive patients with early cervical carcinoma who were treated with pelvic laparoscopic lymphadenectomy and radical surgery underwent sentinel lymph node biopsy following lymphatic mapping with patent blue dye.

First case of a centropelvic recurrence after radical trachelectomy: literature review and implications for the preoperative selection of patients.

Background: To report the first case of a centropelvic recurrence in a patient who underwent a radical trachelectomy (RT) for a stage IB1 cervical carcinoma.

Case: A 32-year-old woman presented with a stage IB1 adenocarcinoma that was treated by radical trachelectomy. The tumor measured 21 x 20 mm.

Laparoscopic assessment of the sentinel lymph nodes in early cervical cancer. Technique--preliminary results and future developments.

Laparoscopic assessment of the sentinel node (SN) in early stage cervical cancer is both feasible and safe. The technique is described. The data concerning the 70 first assessed patients are reported.

Laparoscopic management of adnexal masses in pregnancy: a case series.

Objective: To determine the feasibility, safety, limiting factors, and advantages of laparoscopic management of adnexal masses in pregnancy.

Study Design: During a 12-year period, 48 laparoscopic procedures were performed in 47 patients with adnexal masses in pregnancy. Laparoscopic surgery was done during the first trimester of pregnancy in 17 cases, the second trimester in 27 cases and the third trimester in four cases.

[Carcinomatous transformation of an atypical polypoid adenomyofibroma of the uterus].

We report a case of an atypical polypoid adenomyofibroma (APA) with carcinomatous transformation that occurred in a nulliparous 32 year-old woman treated with estroprogestatives. The well-differentiated mucinous adenocarcinoma was in continuity with the APA, showed a deep myoinvasion and extended to the upper part of the cervix. No hormonal receptor was expressed by tumor cells.

Long-term outcome of a randomized study comparing three techniques of conization: cold knife, laser, and LEEP.

Objective: To evaluate the long-term recurrence rates and complication of different techniques of cervical ablation.

Methods: A randomized trial of three techniques of conization (cold knife, laser, and loop electrosurgical excisional procedure (LEEP)) for cervical intraepithelial neoplasia (CIN) in which 110 patients had been recruited.

Results: Eighty-six patients were followed-up for more than 3 years.

[Extended trachelectomy relapse: plea for patient involvement in the medical decision].

A series of 96 radical trachelectomies performed between April 1987 and May 2002 at Hospital Edouard Herriot in Lyon is reported. One second cancer (bilateral suprarenal glands cancer) and four recurrences were observed. The retrospective unifactorial analysis demonstrated that the maximal tumoral diameter (2 cm or more) and the depth of infiltration (1 cm or more) were the two only significant factors of risk (p = 0.

[Gynecological cancers and pregnancy: the point of view of the oncology gynecologist].

Cervical cancer and nonepithelial ovarian cancer are the most frequent gynecological tumors diagnosed during the pregnancy. The management of patients with a malignant tumor discovered during her pregnancy depends on the type of the tumor, the tumor stage and the term of the pregnancy. In most of cases, a conservative management of the pregnancy could be offered without affect the optimal approach for the treatment of the tumor nor the survival of the patient.