In silico analysis of balsaminol as anti-viral agents targeting SARS-CoV-2 main protease, spike receptor binding domain and papain-like protease receptors.

Unlabelled: Plant-derived phytochemicals from medicinal plants are becoming increasingly attractive natural sources of antimicrobial and antiviral agents due to their therapeutic value, mechanism of action, level of toxicity and bioavailability. The continued emergence of more immune-evasive strains and the rate of resistance to current antiviral drugs have created a need to identify new antiviral agents against SARS-CoV-2. This study investigated the antiviral potential of balsaminol, a bioactive compound from , and its inhibitory activities against SARS-CoV-2 receptor proteins.

Potential of inosine-5'-monophosphate dehydrogenase (IMPDH) and guanosine-5'-monophosphate oxidoreductase (GMPR) as druggable and vaccine candidates: immunoinformatics screening.

Onchocerciasis is a vector-borne disease caused by the filarial nematode , which is responsible for most of the visual impairments recorded in Africa, Asia and the Americas. It is known that has similar molecular and biological characteristics as in cattle. This study was designed to screen for immunogenic epitopes and binding pockets of IMPDH and GMPR ligands using immunoinformatic approaches.