Evaluation of an Engineered Zika Virus-Like Particle Vaccine Candidate in a Mosquito-Mouse Transmission Model.

The primary route of Zika virus (ZIKV) transmission is through the bite of an infected mosquito, when it probes the skin of a vertebrate host during a blood meal. Viral particles are injected into the bite site together with mosquito saliva and a complex mixture of other components. Some of them are known to play a key role in the augmentation of the arbovirus infection in the host, with increased viremia and/or morbidity.

High Temperature Cycles Result in Maternal Transmission and Dengue Infection Differences Between Strains in Aedes aegypti.

Environmental factors play a crucial role in the population dynamics of arthropod endosymbionts, and therefore in the deployment of symbionts for the control of dengue arboviruses. The potential of to invade, persist, and block virus transmission depends in part on its intracellular density. Several recent studies have highlighted the importance of larval rearing temperature in modulating densities in adults, suggesting that elevated temperatures can severely impact some strains, while having little effect on others.