[Oxidative stress in experimental acute glomerulonephritis].

The aim of this study was to estimate the concentration of lipid peroxidation products (TBARS -thiobarbituric acid reactive substances) in serum and in renal cortex, and erythrocytes superoxide dismutase (SOD), glutathione peroxidase (GPx) activity in blood during the development of experimental acute glomerulonephritis. Total antioxidant capacity of plasma and some of plasma nonenzymatic antioxidants, such as total protein level and uric acid were also measured. Acute glomerulonephritis was induced by intravenous injection of bovine serum albumin (BSA) in rabbits, at a dose of 250 mg/kg.

The influence of interferon alpha on the rat liver injured by chronic administration of carbon tetrachloride.

Due to their complex and not fully known etiopathogenesis as well as difficulties in treatment, chronic hepatitis and cirrhosis still remain one of the main problems of hepatologists. Nowadays, the use of IFN alpha is considered the most effective method of treatment in chronic hepatitis. Recently, a new property of IFN, i.

Immunoexpression of nm23 in advanced esophageal squamous cell carcinoma.

The study was undertaken to determine the immunoexpression of protein products of nm23 genes which are thought to be potential metastasis suppressor genes, in esophageal squamous cell carcinoma, and to analyze their relationship to selected clinicopathological features (age, sex, tumour size, depth of invasion, presence of lymph nodes and distant metastasis, pathologic tumor stage, degree of cancer differentiation and vascular/lymphatic invasion), as well as to the overall survival. Immunohistochemical staining with monoclonal antibody against nm23 using LSAB2/HRP method on formalin-fixed, paraffin-embedded sections obtained from 32 tumors was performed. Eight tumors (25%) showed positive nm23 immunoexpression.