Noninvasive Localized Cold Therapy: A New Mode of Bone Repair Enhancement.

A variety of biological, mechanical, and physical therapeutic modalities of varying complexity, efficacy, cost, and safety profile have been developed to enhance bone healing. There have been sporadic reports of spontaneous bone formation after repeated cold exposure. In this study we report for the first time, the anabolic effect of cold exposure on bone healing resulting in a doubling of bone volume.

Assessment transcallosal Diaschisis in a model of focal cerebral ischemia in rats.

Objective: To evaluate transcallosal changes after a local ischemic injury in rats by using the monoclonal marker anti-NeuN (Mouse anti-neuronal nuclei).

Methods: Twenty-eight adult, male, Wistar rats were subjected to focal injury in the right hemisphere. The technique used was the experimental model of focal ischemic injury through intraluminal suture of the middle cerebral artery.

Robust regression of scattered data with adaptive spline-wavelets.

A coarse-to-fine data fitting algorithm for irregularly spaced data based on boundary-adapted adaptive tensor-product semi-orthogonal spline-wavelets has been proposed in Castaño and Kunoth, 2003. This method has been extended in Castaño and Kunoth, 2005 to include regularization in terms of Sobolev and Besov norms. In this paper, we develop within this least-squares approach some statistical robust estimators to handle outliers in the data.