Publications by authors named "Daniel Carvalho-Mendonca"
Free Radic Biol Med
November 2023
Article Synopsis
- Aging is associated with functional decline and mitochondrial dysfunction, largely due to decreased NAD levels and increased activity of the enzyme CD38.
- Research indicates that inhibiting CD38 can improve mitochondrial function in various tissues, but its specific impact on NAD levels and metabolism in the aging brain is still unclear.
- This study reveals that while CD38 does not affect overall NAD levels or mitochondrial oxygen consumption in aging brains, it plays a crucial role in regulating hydrogen peroxide production related to mitochondrial function, suggesting a new link between CD38 and brain energy metabolism in aging.
