Publications by authors named "Daniel Carnevali"
Article Synopsis
- - Plitidepsin, a cyclic-peptide from marine sources, effectively inhibits SARS-CoV-2 replication by targeting an important host protein, showing its strongest effects in lung tissue compared to blood.
- - A clinical study involving 46 hospitalized COVID-19 patients tested three doses of plitidepsin and primarily focused on safety, while also monitoring viral load changes, mortality, and need for respiratory support.
- - The treatment was generally safe, with some common side effects like nausea, vomiting, and diarrhea; early results indicated significant reductions in viral load over time, though a few patients required additional medical support.
Unlabelled: Plitidepsin is a marine-derived cyclic-peptide that inhibits SARS-CoV-2 replication at low nanomolar concentrations by the targeting of host protein eEF1A (eukaryotic translation-elongation-factor-1A). We evaluated a model of intervention with plitidepsin in hospitalized COVID-19 adult patients where three doses were assessed (1.5, 2 and 2.
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