Publications by authors named "Daniel C Moline"
Article Synopsis
- - Benign prostate hyperplasia and prostate cancer both involve excessive growth of prostate tissue, highlighting the need to understand the normal progenitor cells in the prostate and identify potential drug targets.
- - Researchers used single-cell RNA sequencing (scRNA-Seq) to identify a specific population of luminal progenitor cells in the prostate of mice, both with and without hormonal treatment.
- - The study found key factors essential for regenerating prostate organoids from mice and humans, suggesting scRNA-Seq can help uncover potential pharmacologic strategies aimed at the cell populations responsible for prostate diseases.
Benign prostatic hyperplasia (BPH) is a benign enlargement of the prostate in which incidence increases linearly with age, beginning at about 50 years old. BPH is a significant source of morbidity in aging men by causing lower urinary tract symptoms and acute urinary retention. Unfortunately, the etiology of BPH incidence and progression is not clear.
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