Publications by authors named "Daniel C Julien"

A 3.5 year old Hispanic female presented with signs and symptoms concerning for MPS II (Hunter Syndrome). The diagnosis of MPS II was confirmed by enzyme and molecular testing.

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Due to their excellent specificity for a single epitope, monoclonal antibodies (mAbs) present a means of influencing the function of cells at the molecular level. In particular they show great promise in the treatment of cancer because they can inhibit cancer cell proliferation, tumor angiogenesis, invasiveness and malignant spread of cancerous cells. Many mAbs are in various stages of testing and 11 are currently marketed in the US or Europe for the treatment of cancers that express particular antigens such as human epidermal growth factor receptor-2, CD20, epidermal growth factor receptor and vascular endothelial growth factor.

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Article Synopsis
  • Three cell models (HeLa, Panc 10.05, and 3T3-L1) were used to investigate the acute toxicity of silica nanowires (NWs), revealing that NWs inhibited cell proliferation, especially in HeLa cells.
  • After 20 hours of exposure, all cell lines exhibited a significant decrease in metabolic activity, with 3T3-L1 and Panc 10.05 showing delayed effects compared to HeLa.
  • The study found that cell death from silica NWs primarily involved necrosis rather than apoptosis, indicating these cell lines were generally tolerant to the tested doses of NWs.
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