Publications by authors named "Daniel C Chang"
Article Synopsis
- Apoptosis is a crucial process in multicellular organisms that helps eliminate unwanted cells, but when it’s dysregulated, it can lead to diseases like cancer and neurodegenerative disorders.
- Caspase-3 plays a key role in the later stages of apoptosis by cleaving certain substrates, which is essential for the process of programmed cell death.
- Researchers developed a novel imaging platform that uses a recombinant protein to visualize caspase-3 activation in cells, allowing for real-time observation of apoptosis and potentially aiding the discovery of new therapeutic agents.
In an effort to identify a clinical biomarker for lung cancer, we used cDNA microarray and 2D protein analyses to demonstrate that increased Fas-associated death domain (FADD) mRNA and protein were significantly associated with poor survival. Analyses of copy number and sequence of the FADD gene in 24 independent tumors ruled out the existence of an amplified and/or mutated FADD gene in aggressive lung cancers. Immunohistochemistry-based tissue microarray analysis showed that nuclear localization of FADD and elevation of the phosphorylated form of FADD (p-FADD) correlated with poor outcome (P = 0.
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