Model-Based Explanation of Feedback Effects in Syllogistic Reasoning.

For decades, a significant number of models explaining human syllogistic inference processes were developed. There is profound work fitting the models' parameters and analyzing each model's ability to account for the data in order to support or reject the underlying theories. However, the model parameters are rarely used to extract explanations and hypotheses for phenomena that go beyond the original scope of the models.

Generation of an NFκB-Driven Alpharetroviral "All-in-One" Vector Construct as a Potent Tool for CAR NK Cell Therapy.

Immune cell therapeutics are increasingly applied in oncology. Especially chimeric antigen receptor (CAR) T cells are successfully used to treat several B cell malignancies. Efforts to engineer CAR T cells for improved activity against solid tumors include co-delivery of pro-inflammatory cytokines in addition to CARs, either constitutive cytokine expression or inducible cytokine expression triggered by CAR recognition of its target antigen-so-called "T cells redirected for universal cytokine-mediated killing" (TRUCKs) or fourth-generation CARs.

The Predictive Power of Spatial Relational Reasoning Models: A New Evaluation Approach.

In the last few decades, cognitive theories for explaining human spatial relational reasoning have increased. Few of these theories have been implemented as computational models, however, even fewer have been compared computationally to each other. A computational model comparison requires, among other things, a still missing quantitative benchmark of core spatial relational reasoning problems.

Genetic Correction of IL-10RB Deficiency Reconstitutes Anti-Inflammatory Regulation in iPSC-Derived Macrophages.

Patient material from rare diseases such as very early-onset inflammatory bowel disease (VEO-IBD) is often limited. The use of patient-derived induced pluripotent stem cells (iPSCs) for disease modeling is a promising approach to investigate disease pathomechanisms and therapeutic strategies. We successfully developed VEO-IBD patient-derived iPSC lines harboring a mutation in the IL-10 receptor β-chain (IL-10RB) associated with defective IL-10 signaling.

Predictive Modeling of Individual Human Cognition: Upper Bounds and a New Perspective on Performance.

Model evaluation is commonly performed by relying on aggregated data as well as relative metrics for model comparison and selection. In light of recent criticism about the prevailing perspectives on cognitive modeling, we investigate models for human syllogistic reasoning in terms of predictive accuracy on individual responses. By contrasting cognitive models with statistical baselines such as random guessing or the most frequently selected response option as well as data-driven neural networks, we obtain information about the progress cognitive modeling could achieve for syllogistic reasoning to date, its remaining potential, and upper bounds of performance future models should strive to exceed.

Modeling Human Syllogistic Reasoning: The Role of "No Valid Conclusion".

Syllogistic reasoning, that is the drawing of inferences for categorical-quantified assertions, is one of the oldest branches of deductive reasoning research with a history exceeding 100 years. In syllogistic reasoning experiments, "No Valid Conclusion" (NVC) is one of the most frequently selected responses and corresponds to the logically correct conclusion for 58% of the syllogistic problem domain. To date, NVC is often neglected in computational models or just treated as a by-product of the underlying inferential mechanisms such as a last resort when the search for alternatives is exhausted.

Hematopoietic stem cell gene therapy for IFNγR1 deficiency protects mice from mycobacterial infections.

Mendelian susceptibility to mycobacterial disease is a rare primary immunodeficiency characterized by severe infections caused by weakly virulent mycobacteria. Biallelic null mutations in genes encoding interferon gamma receptor 1 or 2 ( or ) result in a life-threatening disease phenotype in early childhood. Recombinant interferon γ (IFN-γ) therapy is inefficient, and hematopoietic stem cell transplantation has a poor prognosis.