Publications by Daniel Bejar

Publications by authors named "Daniel Bejar"

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Methotrexate induces germ cell apoptosis and impairs spermatogenesis in a rat.

Igor Sukhotnik Omri Nativ Alex Roitburt Daniel Bejar Arnold G Coran

Pediatr Surg Int

February 2013

Purpose: The primary toxic effects of methotrexate (MTX) are myelosuppression and/or intestinal mucositis. The objective of the present study is to investigate the effect of MTX on germ cell apoptosis and spermatogenesis in a rat.

Methods: Male Sprague-Dawley rats were divided into three experimental groups: control rats treated with vehicle; MTX-2 rats treated with one dose (20 μg/kg) of MTX given IP and killed on the second day; and MTX rats treated with IP MTX (20 μg/kg) and killed on day 4.

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