Publications by authors named "Daniel Baumel"
Following their first interaction with the antigen, quiescent naive T-helper (Th; CD4) cells enlarge, differentiate, and proliferate; these processes are accompanied by substantial epigenetic alterations. We showed previously that the epigenetic regulators the polycomb-group (PcG) proteins have a dual function as both positive and negative transcriptional regulators; however, the underlying mechanisms remain poorly understood. Here, we demonstrate that during Th cell differentiation the methyltransferase activity of the PcG protein Ezh2 regulates post-transcriptionally inducible assembly of intranuclear actin filaments.
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- - The study explores the prevalence of the nt230(del4) MDR1 mutation, which affects sensitivity to certain veterinary drugs, particularly in Rough Collies and other breeds, with data collected from 1,416 dogs in Israel.
- - Frequencies of the mutation in Israeli breeds like Australian Shepherds and German Shepherds align with global figures, while Border Collies show higher rates and Rough Collies lower rates compared to other regions.
- - The findings highlight the need for careful treatment and breeding practices among affected dog breeds and their crosses in Israel, indicating that the true proportion of affected dogs might be understated due to selective sampling by veterinarians.