Response to dual antiplatelet therapy in patients with peripheral artery occlusive disease suffering from critical limb ischemia.

Background: Failure to reach the level of therapeutic anticoagulation represents a risk factor for occlusive events in patients suffering from peripheral arterial disease. Our study aimed to analyze the prevalence of nonresponse to dual antiplatelet therapy in a group of patients admitted to our hospital with critical limb ischemia (CLI) following stent-thrombosis.

Methods: This prospective study was approved by the local Ethics Review Board.

Aggregometric assessment of clonidine's impact on the efficacy of dual platelet inhibition.

Background: Clonidine is commonly used as a calmative and antihypertensive agent in perioperative care. Due to the drug's alpha-2-agonistic effects, it has recently been hypothesised that clonidine may affect platelet aggregability. The present investigation aimed to study the potential impact of clonidine on the efficacy of dual antiplatelet therapy.