Publications by authors named "Daniel B Ibsen"

Article Synopsis
  • - This study examines the link between long-term alcohol consumption patterns and the risk of breast cancer in postmenopausal women, using data from nearly 29,000 women aged 50-65 from a Danish cohort.
  • - Researchers identified four different alcohol consumption profiles and found that women whose average intake exceeded 10g per day had a significantly higher risk of developing breast cancer compared to those who consumed less than 6g per day.
  • - The findings show that a consistent high alcohol intake throughout adulthood increased breast cancer risk, while women with lower alcohol intake during early adulthood who later increased their consumption did not show a higher risk compared to those with consistently low intake.
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  • A study analyzed the link between different levels of food processing and the risk of developing type 2 diabetes, using data from the EPIC cohort involving nearly 312,000 participants over about 11 years.
  • The results showed that higher intake of ultra-processed foods (UPF) was significantly associated with an increased risk of type 2 diabetes, while unprocessed/minimally processed foods and processed foods were linked to a lower risk.
  • Sub-group analysis revealed specific types of UPF, like certain breads and plant-based alternatives, that, surprisingly, were associated with a reduced risk of developing type 2 diabetes.
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Primary liver cancer is globally on the rise, partially due to poor diets and sedentary lifestyles. Shifting to more plant-based diets may lower the risk. We aimed to estimate the effect of replacing total red meat, unprocessed red meat and processed red meat with legumes on primary liver cancer in a free-living population.

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  • Nutrition science aims to pinpoint how diet influences health and disease to guide public health policies and clinical practices.
  • Conflicting results from research make it hard to draw clear conclusions, partly because studies may be asking different questions about diet and disease.
  • Addressing the complexity of dietary data—including how food changes affect overall diet, the layered nature of nutrients in foods, and the lifelong impact of diet—can help produce clearer evidence for policy-making.
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  • The study aimed to compare different dietary scores derived from the EAT-Lancet reference diet and examine their links to health outcomes like mortality and stroke incidence, as well as their environmental impacts related to greenhouse gas emissions.
  • A systematic review identified seven different diet scores and analyzed their effectiveness in categorizing participants according to the EAT-Lancet recommendations across three diverse cohorts: Danish, Swedish, and Mexican populations.
  • The findings indicated that two scores (Stubbendorff and Colizzi) effectively grouped participants based on adherence to the EAT-Lancet diet, with higher scores correlating to a lower risk of all-cause mortality and stroke events.
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Purpose Of Review: This review highlights recent developments in understanding the role of dietary fibre and specific fibre types on risk and management of cardiometabolic disease with a focus on the causal pathways leading to cardiometabolic diseases, namely weight management, glycaemic control, and lipid levels, as well as the latest findings for cardiovascular disease outcomes such as coronary heart disease, stroke, and mortality. Evidence for mechanisms through gut microbiota are also briefly reviewed.

Recent Findings: Dietary fibre intake is associated with improved weight management, the extent of which may depend on the subtype of dietary fibre.

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Article Synopsis
  • - The study examined how following the EAT-Lancet diet affects body weight and waist circumference (WC) over five years among midlife participants from Denmark.
  • - Results indicated that while adherence to the diet didn’t lead to significant changes in weight, it was linked to a lower waist circumference and reduced risk of obesity.
  • - The findings suggest that the EAT-Lancet diet is beneficial for waist size but does not contribute to weight gain over time.
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  • Epidemiological studies suggest that the link between dietary protein intake and cardiovascular disease (CVD) might depend on whether the protein is plant- or animal-based, but previous research has been inconclusive.
  • The analysis involved over 16,000 CVD cases and aimed to assess how different protein sources impact the risk of CVD, ischemic heart disease (IHD), and stroke using various statistical methods.
  • Findings revealed that plant-derived protein intake was associated with a lower incidence of total stroke in never smokers, especially when replacing red and processed meat proteins, but overall, neither protein source showed a significant association with CVD, IHD, or stroke risk.
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Nordic Nutrition Recommendations recommend reducing red and processed meat and increasing fish consumption, but the impact of this replacement on mortality is understudied. This study investigated the replacement of red and processed meat with fish in relation to mortality. Of 83 304 women in the Norwegian Women and Cancer Study (NOWAC) study, 9420 died during a median of 21·0 years of follow-up.

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Background Observational studies have shown that women with an early menopause are at higher risk of stroke compared with women with a later menopause. However, associations with stroke subtypes are inconsistent, and the causality is unclear. Methods and Results We analyzed data of the UK Biobank and EPIC-CVD (European Prospective Investigation Into Cancer and Nutrition-Cardiovascular Diseases) study.

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We used design principles of target trial methodology to emulate the effect of sustained adherence to the Dietary Approaches to Stop Hypertension (DASH) diet on the 22-year risk of heart failure. Women and men aged 45-83 years without previous heart failure, who answered questionnaires in 1997 from the Swedish Mammography Cohort and the Cohort of Swedish Men, were eligible. Follow-up questionnaires were sent in 2008-2009.

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Purpose: Type 2 diabetes is a global health problem. While a healthy diet lowers risk of type 2 diabetes, less is known about diets with low climate impact. This study aimed to investigate adherence to the EAT-Lancet diet and risk of type 2 diabetes in a Danish setting.

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Article Synopsis
  • Scientists found a link between how processed our food is and the risk of getting certain diseases.
  • They used something called the Nova classification, which sorts foods into four groups based on how much they've been processed.
  • In this study, they looked at nearly half a million people in Europe to see how different cultural backgrounds affected what kind of processed foods they ate and how that related to specific health markers in their bodies.
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Aims: Trials demonstrate that following the DASH diet lowers blood pressure, which may prevent the development of heart failure (HF). We investigated the association between long-term adherence to the DASH diet and food substitutions within the DASH diet on the risk of HF.

Methods And Results: Men and women aged 45-83 years without previous HF, ischaemic heart disease or cancer at baseline in 1998 from the Cohort of Swedish Men (n = 41 118) and the Swedish Mammography Cohort (n = 35 004) were studied.

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Background And Purpose: We investigated the association between adherence to the EAT-Lancet diet, a sustainable and mostly plant-based diet, and risk of stroke and subtypes of stroke in a Danish population. For comparison, we also investigated the Alternate Healthy Eating Index-2010 (AHEI).

Methods: We used the Danish Diet, Cancer and Health cohort (n=55 016) including adults aged 50 to 64 years at baseline (1993-1997).

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Background: Unhealthy diets, the rise of non-communicable diseases, and the declining health of the planet are highly intertwined, where food production and consumption are major drivers of increases in greenhouse gas emissions, substantial land use, and adverse health such as cancer and mortality. To assess the potential co-benefits from shifting to more sustainable diets, we aimed to investigate the associations of dietary greenhouse gas emissions and land use with all-cause and cause-specific mortality and cancer incidence rates.

Methods: Using data from 443 991 participants in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, a multicentre prospective cohort, we estimated associations between dietary contributions to greenhouse gas emissions and land use and all-cause and cause-specific mortality and incident cancers using Cox proportional hazards regression models.

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Background: Food biodiversity, encompassing the variety of plants, animals, and other organisms consumed as food and drink, has intrinsic potential to underpin diverse, nutritious diets and improve Earth system resilience. Dietary species richness (DSR), which is recommended as a crosscutting measure of food biodiversity, has been positively associated with the micronutrient adequacy of diets in women and young children in low- and middle-income countries (LMICs). However, the relationships between DSR and major health outcomes have yet to be assessed in any population.

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Background: National dietary guidelines contribute to primary prevention of a wide range of diseases. Yet, the importance of adhering to the Danish dietary guidelines for colorectal cancer prevention is unclear.

Methods: We used the Danish Diet, Cancer and Health cohort (n = 55,744) to investigate adherence to the Danish dietary guidelines and the risk of colorectal cancer.

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Introduction: Modifiable lifestyle behaviors represent a central target for public health interventions. This study investigates the association between adherence to 4 modifiable lifestyle recommendations and all-cause, cancer, or cardiovascular disease mortality.

Methods: Investigators used data from the Danish Diet, Cancer and Health cohort (1993-2013; N=54,276).

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Background: Few cohort studies have modelled replacements of red meat with other sources of protein on subsequent risk of type 2 diabetes using dietary changes.

Objectives: To determine whether replacing red meat with other food sources of protein is associated with a lower risk of type 2 diabetes.

Methods: We used data from the Danish Diet, Cancer, and Health cohort (n = 39,437) of middle-aged (55-72 years old) men and women who underwent 2 dietary assessments roughly 5 years apart to investigate dietary changes.

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Purpose: We investigated the association between an increased intake of one dairy product subgroup at the expense of another within a 5-year period and the subsequent 10-year risk of type 2 diabetes.

Methods: The cohort included 39,393 adults with two measurements of diet assessed using food frequency questionnaires (FFQ) administered in 1993-1997 and 1999-2003. Dairy products were milk (skimmed, semi-skimmed, whole fat), buttermilk, low-fat yogurt, whole-fat yogurt, cheese and butter.

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