Transfer factor and allergy.

Although various mechanisms involving antibodies and various cell types participate, a Thl and Th2 cells imbalance seems to play a central role for allergy development. Other lymphocyte subpopulations, such as Th17, CD4 FOXP3, and Th9 positive regulatory T lymphocytes may also be involved in the allergic response. Regulatory processes are an appealing target for therapeutic approaches aiming to solve allergic reactions by restoring the delicate balance within the immune system.

[Sensitization to Blomia tropicalis and Dermatophagoides pteronyssinus, farinae and siboney prevalence in patients with rhinitis, allergic asthma, or both, in a population of a metropolitan area of Mexico City].

Background: The increased prevalence of asthma has been associated with an increase in atopic sensitization, and it is parallel with similar increases in other allergic diseases. In United States, Blomia tropicalis has the fourth place between the most known types of house dust mites, and is the most common in the southern subtropical states. In Mexico there have been few studies to investigate sensitization to this mite.

[Ocular findings most frequently found in patients with allergic rhinoconjunctivitis].

Background: Allergic etiology is suspected whenever a patient with conjunctivitis presents the typical clinical features; however, in ophthalmic practice, confirmation of the immune disease is uncommon. Ocular involvement is common in allergic rhinitis, and the current name of this entity is allergic rhinoconjunctivitis (ARC). Conjunctivitis diagnosis in ARC is inferred by the symptoms, but the most common ocular findings in patients with a confirmed allergic disease are unknown.

[Th1 and Th2 lymphocytes in perennial allergic rhinitis].

Background: The study of perennial allergic rhinitis is a good model to evidence the unbalance between Th1 and Th2 lymphocytes. This functional unbalance is manifested by the exaggerated production of pro-inflammatory cytokines and a reduction of the antiinflammatory ones.

Objective: To corroborate these alterations in patients with perennial allergic rhinitis.

[Lymphocytes B and NK in respiratory allergy].

Background: High affinity immunoglobulin E (IgE) receptors may activate the mast cell degradation; on the other hand, the ones of low affinity may activate B lymphocytes so they act as antigen-presenting cells and as producers of the same immunoglobulin. As allergic patients produce a great quantity of IgE they are prone to get an infection.

Objective: To quantify the IgE increase in 28 patients with allergic rhinitis or asthma, or both without having received a previous treatment.

[Assessment of the clinical efficacy and safety of epinastine plus pseudoephedrine vs loratadine plus pseudoephedrine in perennial allergic rhinitis].

Background: Several drugs for the treatment of perennial allergic rhinitis and its symptoms have been investigated since some years ago. These drugs are: steroidal-type immunoregulators, immunotherapy and antihistamines. Because of first generation of the last ones originated several side effects, pharmacological research was oriented to the search of formulas with the same of higher efficacy, but with fewer effects on central nervous system.

[Th1 lymphocytes in patients with extrinsic asthma].

Background: Bronchial asthma is a multifactorial disease affecting the functionality of the bronchial tree and immunological changes.

Objective: To determine if lymphocytes Th-1 have a role in extrinsic asthma of Mexican patients.

Material And Methods: We included in the study 39 patients with extrinsic asthma, living in Mexico City, and 27 healthy subjects, without allergy antecedents, with nutritional and immunological characteristics similar.