An evolutionary recent IFN/IL-6/CEBP axis is linked to monocyte expansion and tuberculosis severity in humans.

Monocyte counts are increased during human tuberculosis (TB) but it has not been determined whether () directly regulates myeloid commitment. We demonstrated that exposure to directs primary human CD34 cells to differentiate into monocytes/macrophages. In vitro myeloid conversion did not require type I or type II IFN signaling.