Targeted Prostate Biopsy Gleason Score Heterogeneity and Implications for Risk Stratification.

Objectives: To quantify Gleason score (GS) heterogeneity within multiparametric magnetic resonance imaging (MRI)-targeted prostate biopsies and to determine impact on National Comprehensive Cancer Network (NCCN) risk stratification.

Methods: An Institutional Review Board-approved retrospective study was performed on men who underwent Artemis (MRI-transrectal-ultrasound fusion) targeted biopsy (TB) for suspected prostate cancer between 2012 and 2015. Intratarget heterogeneity was defined as a difference in GS between 2 cores within a single target in patients with ≥2 positive cores.

Rapid quantitative T mapping of the prostate using three-dimensional dual echo steady state MRI at 3T.

Purpose: To develop and evaluate a rapid three-dimensional (3D) quantitative T mapping method for prostate cancer imaging using dual echo steady state (DESS) MRI at 3T.

Methods: In simulations, DESS-T mapping in the presence of T and B1+ variations was evaluated. In a phantom and in healthy volunteers (n = 4), 3D DESS-T mapping was compared with a two-dimensional turbo spin echo (TSE) approach.

Accelerated echo planar J-resolved spectroscopic imaging in prostate cancer: a pilot validation of non-linear reconstruction using total variation and maximum entropy.

The overlap of metabolites is a major limitation in one-dimensional (1D) spectral-based single-voxel MRS and multivoxel-based MRSI. By combining echo planar spectroscopic imaging (EPSI) with a two-dimensional (2D) J-resolved spectroscopic (JPRESS) sequence, 2D spectra can be recorded in multiple locations in a single slice of prostate using four-dimensional (4D) echo planar J-resolved spectroscopic imaging (EP-JRESI). The goal of the present work was to validate two different non-linear reconstruction methods independently using compressed sensing-based 4D EP-JRESI in prostate cancer (PCa): maximum entropy (MaxEnt) and total variation (TV).