Retrieving autobiographical memories in autobiographical contexts: are age-related differences in narrated episodic specificity present outside of the laboratory?

The Autobiographical Interview, a method for evaluating detailed memory of real-world events, reliably detects differences in episodic specificity at retrieval between young and older adults in the laboratory. Whether this age-associated reduction in episodic specificity for autobiographical event retrieval is present outside of the laboratory remains poorly understood. We used a videoconference format to administer the Autobiographical Interview to cognitively unimpaired older adults (N = 49, M = 69.

Protocol to Induce the Temporary Opening of the Blood-Brain Barrier with Short-Time Focused Ultrasound in Rats.

Brain neurodegenerative diseases are central nervous system (CNS) affections typically common in older adults. A new therapeutic approach for them consists of providing specific drugs to the CNS through blood circulation; however, the Blood-Brain Barrier (BBB) prevents almost 100% of neurotherapeutics from reaching the brain. There are indications that Focused Ultrasound (FUS), temporarily placed in the BBB, can achieve a controlled increase in temperature at its focus, allowing temporary, localized, and reversible opening of this barrier, which facilitates the temporary delivery of specific drugs.

Nebulette is a powerful cytolinker organizing desmin and actin in mouse hearts.

In the hearts of patients bearing nebulette mutations, a severe general disorganization in cardiomyocytes of the extrasarcomeric desmin intermediate filament system is frequently observed. However, the molecular and functional relationship between the desmin cytoskeleton and nebulette-containing sarcomeres is still unclear. Here we report a high-affinity in vitro interaction between nebulette and desmin filaments.

[Teaching of medicine of the University of Bologna in the Reinaissance].

The foundation date of the University of Bologna was 1150, was the first European University and set the pattern. The combination of structured teaching and students association marked the origin of the studium generale. The presence of teaching legists encouraged teachers in others fields to come to Bologna.

Metabolic responses to the seated calf press exercise performed against inertial resistance.

Introduction: Future in-flight strength training devices may use inertial resistance to abate mass and strength losses to muscle groups such as the triceps surae, which incurs pronounced deficits from space travel. Yet little data exist regarding physiological outcomes to triceps surae exercise performed against inertial resistance. Two sets of subjects were employed to note either blood lactate (La-) or net caloric cost responses to seated calf presses done on an inertial resistance ergometer.

A comparison of isoload and isoinertial leg press training on bone and muscle outcomes.

The subjects of this study (n = 20; 16 women, 4 men) performed 10 weeks of leg press training using one of two exercise modes (isoload or isotonic) with no crossover. Their workouts, which were performed 3 times per week, involved 4 sets of 8 repetitions with maximal voluntary effort. Testing was performed pre- and posttraining to examine bone and muscle changes.

A multivariate approach to predicting knee extensor performance.

The impact of two predictor variables (estimated knee extensor fast-twitch fiber percentage, body mass) on performance measures (vertical jump power output, leg press peak angular velocity) were examined. Subjects (25 men, 27 women) performed 5 workouts involving 2 vertical jump, leg press, and 50-repetition isokinetic tests (to estimate knee extensor fast-twitch fiber percentage). Multivariate regression determined the following significant (p < 0.

Inclusion of eccentric actions on net caloric cost resulting from isoinertial resistance exercise.

Net O(2) uptake was measured from maximal-effort 3-set, 8-repetition seated leg press protocols on an isoinertial ergometer. Subjects (25 women, 9 men) did 2 workouts each exerting concentric-eccentric (CE) and concentric-only (CO) knee extensor forces to measure work and net caloric cost. Significant (p < 0.