Publications by authors named "Daniel A Graf"
Patients often recognize unmet needs that can improve patient-provider experiences in disease treatment management. These needs are rarely captured and may be hard to quantify in difficult-to-treat disease states such as drug-resistant epilepsy (DRE). To further understand challenges living with and managing DRE, a team of medical anthropologists conducted ethnographic field assessments with patients to qualitatively understand their experience with DRE across the United States.
View Article and Find Full Text PDFUnlabelled: In a single-arm, phase 2 clinical trial, bendamustine-rituximab (BR) demonstrated an overall response rate of 82% among 45 patients with relapsed or refractory mantle cell lymphoma (MCL), with manageable tolerability. A prespecified F-FDG PET analysis was conducted to assess the predictive value of the metabolic response to BR compared with the response by International Working Group (IWG) criteria.
Methods: Adult patients with relapsed or refractory MCL underwent F-FDG PET at screening and after 6 cycles of BR therapy.
Although primary neuronal cells are routinely used for neuroscience research, with potential clinical applications such as neuronal transplantation and tissue engineering, a gold standard protocol for preservation has not been yet developed. In the present work, a slow cooling methodology without ice seeding was studied and optimized for cryopreservation of rat cerebellar granular cells. Parameters such as cooling rate, plunge temperature and cryoprotective agent concentration were assessed using a custom built device based on Pye's freezer idea.
View Article and Find Full Text PDFBackground: Slow cooling is a cryopreservation methodology where samples are cooled to its storage temperature at controlled cooling rates.
Objective: Design, construction and evaluation of a simple and low cost device for slow cooling of small biological samples.
Materials And Methods: The device was constructed based on Pye's freezer idea.