No association between the DRD3 Ser9Gly polymorphism and schizophrenia.

Objective: To investigate the association between a Ser9Gly polymorphism of the dopamine D3 receptor gene (DRD3) and schizophrenia.

Methods: 408 schizophrenic patients and 172 control subjects were compared with regard to their DRD3 Ser9Gly genotypic and allelic frequencies. In addition, we carried out a family-based association study including 183 pedigrees (472 subjects) using the transmission disequilibrium test (TDT).

Association study of the trinucleotide repeat polymorphism within SMARCA2 and schizophrenia.

Background: Brahma (BRM) is a key component of the multisubunit SWI/SNF complex, a complex which uses the energy of ATP hydrolysis to remodel chromatin. BRM contains an N-terminal polyglutamine domain, encoded by a polymorphic trinucleotide (CAA/CAG) repeat, the only known polymorphism in the coding region of the gene (SMARCA2). We have examined the association of this polymorphism with schizophrenia in a family-based and case/control study.

[Antipsychotic medication in psychosocial rehabilitation].

The strategy and points of medication and the use of antipsychotics in the phase of psychosocial rehabilitation substantially different from that we use in the acute treatment. While in the acute phase the primary goal is the symptom-reduction as soon as possible, the goal in the psychosocial rehabilitation is the maintenance of the symptom-free remission state, as long as possible in a stable way, providing the best functioning and best available quality of life with minimal loss of capacities and skills. The basis of the lasting, stable remission and of the successful psychosocial rehabilitation is the effective, safe and tolerable pharmacotherapy, in which the antipsychotics play essential role.

A case report: Pavlovian conditioning as a risk factor of heroin 'overdose' death.

Background: The authors present a case illustrating a mechanism leading directly to death which is not rare but has received little attention.

Case Presentation: The case was evaluated by autopsy, investigation of morphine concentration in the blood, and clinical data. The heroin dose causing the 'overdose' death of a young man who had previously been treated a number of times for heroin addiction did not differ from his dose of the previous day taken in the accustomed circumstances.

CAA insertion polymorphism in the 3'UTR of Nogo gene on 2p14 is not associated with schizophrenia.

The Nogo gene was putatively implicated in schizophrenia based on gene expression and genetic association data. In this study, we attempt to replicate the possible association of the CAA insertion and a nearby TATC deletion with schizophrenia in 204 complete and incomplete triads and in a sample of 462 unrelated cases and 153 controls, all of Caucasian origin. Our genotyping results indicated that neither the trinucleotide insertion polymorphism (CAAins; 43.