1,25-dihydroxyvitamin D and PTHrP mediated malignant hypercalcemia in a seminoma.

Background: Seminomas have been rarely associated with malignant hypercalcemia. The responsible mechanism of hypercalcemia in this setting has been described to be secondary to 1,25-dihydroxyvitamin D secretion. The relationship with PTHrP has not been determined or studied.